| Protective Effect of Topically Applied Polypeptide from Chlamys farreri Against Ultraviolet Radiation-Induced Chronic Skin Damage in Guinea Pig |
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| 作者姓名： | 迟明亮 曹鹏利 于国英 朱莉 王跃军 王春波 |
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| 作者单位： | Medical College，Qingdao University，Qingdao266021，China，Medical College，Qingdao University，Qingdao266021，China，Medical College，Qingdao University，Qingdao266021，China，Medical College，Qingdao University，Qingdao266021，China，Medical College，Qingdao University，Qingdao266021，China，Medical College，Qingdao University，Qingdao266021，China |
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| 基金项目： | ProjectNo.3 9970 63 8supportedbytheNSFC，andtheScienceandTechnologyBureauofQingdao (No.2 0 0 1 2 8 5 0 ) |
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| 摘 要： | INTRODUCTIONSolarultraviolet(UV)radiationisknowntobeamajoretiologicalriskofphotoaging.AsUVC(2 0 0nm -2 90nm)isabsorbedentirelybythestratosphericozonelayer,sunlightontheearthsur faceiscomposedofUVA (3 2 0nm -4 0 0nm)andUVB (2 90nm -3 2 0nm)only.UVAradiationenergyaccountsformorethan 90 %ofsolarUV ;andpenetratesthebasallayerofepidermismoreefficientlythanUVB (Brulsetal.,1984) .However,atsimilardosages,UVBismuchmoremuta genicthanUVA (Drobetskyetal.,1995) .Furthermore ,humanskinisexp…
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| 关 键 词： | 多肽 紫外线辐射 放射线 感应 过氧化物 抗氧化剂 |
Protective Effect of Topically Applied Polypeptide from Chlamys farreri Against Ultraviolet Radiation-Induced Chronic Skin Damage in Guinea Pig |
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| CHI Mingliang,CAO Pengli,YU Guoying,ZHU Li,WANG Yuejun,WANG Chunbo.Protective Effect of Topically Applied Polypeptide from Chlamys farreri Against Ultraviolet Radiation-Induced Chronic Skin Damage in Guinea Pig[J].Chinese Journal of Oceanology and Limnology,2003,21(4):319-323. |
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| Authors: | CHI Mingliang CAO Pengli YU Guoying ZHU Li WANG Yuejun WANG Chunbo |
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| Institution: | CHI Mingliang,CAO Pengli,YU Guoying,ZHU Li,WANG Yuejun,WANG Chunbo ** |
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| Abstract: | Polypeptide from Chlamys farreri (PCF) , a topical polypeptide isolated from Chlamys farreri , was used in this experiment aimed to investigate the photoprotective effect of PCF against chronic skin damage induced by ultraviolet A (UVA) and ultraviolet B (UVB) radiation. The chronic ultraviolet irradiated guinea pig model was established, and visible changes in the skin including wrinkling, sagging and erythema were observed. Malondialdehyde (MDA) and antioxidant enzymes including superoxide dismutase (SOD) and glutathione peroxidase (GSH px) in the dorsal skin were determined using biochemical methods. The results showed:(1)PCF (5 % and 20%) could greatly protect the dorsal skin of guinea pig against wrinkling, sagging and erythema induced by UV radiation in a concentration dependent manner.(2)PCF could reduce MDA formation in the dorsal skin caused by UV irradiation, while increasing the activities of SOD and GSH px.(3)The differences among the PCF groups and UV model group were significant ( P <0.05, P <0.01). These results indicated that topical application of PCF provided broad solar UV spectrum photoprotection; and that the antioxidant property of PCF might play a role in photoprotection. |
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| Keywords: | polypeptide from Chlamys farreri ultraviolet radiation photoprotection antioxidant guinea pig |
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