Land use based on landscape ecological security pattern provides a scientific basis for alleviating conflicts between land conservation and human use, ensuring concomitant economic development and ecological integrity. The majority of studies by Chinese researchers have been focused on the carrying capacity and land development intensity, and less attention has been paid to the ecological security pattern of the landscape in Mianzhu in the transitional zone between the Chengdu Plain region and the Longmen Mountains, western China. However, land resources are undergoing significant changes resulting from land use associated with rapid economic development and demographic growth. In this study, we constructed a minimum cumulative resistance model in Mianzhu in the transitional zone, and the land space was divided into optimized development areas, key development areas, restricted development areas, and prohibited development areas according to the landscape ecological security pattern based on the model surface. These land use types covered 7218.39 ha, 17,974.75 ha, 21,545.39 ha, and 77,791.46 ha, respectively. We also examined land use changes over the last 20 years and quantitatively analyzed the relationships between land use changes and geographic factors based on remote sensing and geographic information system. The information obtained from this research ultimately impacts future policies and plans regarding land resources and can be used to promote the sustainable use of land resources in the region.