A preliminary study targeting to evaluate the local seismic response was performed in the eastern flank of Mt. Etna (southern Italy) using ambient noise measurements. The obtained spectral ratios were subdivided through cluster analysis into different classes of fundamental frequency permitting to draw an iso-frequency contour map. The analysis set into evidence the extreme heterogeneity of lava sequences, which makes difficult to identify a single seismic bedrock formation. Another important outcome, concerning the local seismic effects in terms of frequency and azimuth, is the important role played by the fracture fields associated with the main structural systems of the area. The existence of two zones with strong directional effects striking WNW–ESE and NW–SE, nearly orthogonal to the orientation of the main fracture fields, corroborate such hypothesis.