The shift to building capacity and the loss of regional equilibrium may undermine service delivery and create a hardness issue for governmental and non-governmental organizations. Different countries follow different frameworks for regional equilibrium to evaluate the results of their actions. To achieve good regional equilibrium, we have performed a comparative analysis between the 10 existing frameworks and put 5 main criteria along with 60 sub-criteria in a checklist. We examined the method of measuring these components with the help of various indicators and to distribute weight between these indicators, we consulted experts. Finally, Iran is discussed with examples of direct indicators that may be used to measure the sub-criteria of each specific criterion. The quantification process is also shown by several specific representative indicators. For example, Mobile phones to the population, general practitioners per population, health and social employees to the population. Researchers, policy-makers, decision-makers, and decision takers, are those who can use the method studied in this study to assess the level of regional equilibrium in their country specifically and according to the environmental conditions and the current situation in the region.