Does CYP1A1polymophism increase the risk for cancer in pollution exposure? A study by gene ontology |
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| Authors: | Viroj Wiwanitkit |
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| Institution: | (1) Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, 10330 Bangkok, Thailand |
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| Abstract: | Many genetic polymorphisms in metabolism enzymes are important for the risk of cancer as shown in a large number of case-control
studies. Cytochrome P-450 (CYP) 1A1 polymorphism is a widely mentioned for importance of its genetic polymorphisms in risk
assessment. However, the reports on the correlation between polymorphism and risk are inconsistent. To study the functional
aberration in the human wild and mutate types of CYP1A1 is hard. Here, the author used a new gene ontology technology to predict
the molecular function of human CYP1A1. Here, it can be seen that there is no functional difference between wild and mutate
types of CYP1A1. Therefore, there should be no difference in effect of wild and mutate types of CYP1A1. This can support the
null effect of this polymorphism in clinical findings of the population. This polymorphism might not be an important tool
for risk assessment. |
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| Keywords: | CYP1A1 Polymorphism Function |
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