Biomarker responses in caged rockfish (Sebastes schlegeli) from Masan Bay and Haegeumgang,South Korea |
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| Institution: | 1. Unit for Environmental Sciences and Management, North-West University, Private Bag X1290, Potchefstroom 2520, South Africa.;2. Department of Veterinary Biomedical Sciences, Toxicology Centre, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B4, Canada,;3. Department of Zoology, Centre for Integrative Toxicology, Michigan State University, East Lansing, MI 48824, USA;4. Department of Biology and Chemistry, State Key Laboratory in Marine Pollution, City University of Hong Kong, Kowloon, Hong Kong, China;5. School of Biological Sciences, University of Hong Kong, Hong Kong, China;6. State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210093, Jiangsu, China;7. Coastal Systems Research Group, Council for Scientific and Industrial Research (CSIR), Durban, South Africa;8. Nelson Mandela University, P.O. Box 77000, NMU, Port Elizabeth 6031, South Africa;1. Office of Research and Development, US EPA, Cincinnati, OH, USA;2. Department of Ecology, State of Washington, Lacey, WA, USA;3. Department of Marine Chemistry and Geochemistry, Woods Hole Oceanographic Institution, Woods Hole, MA, USA;4. Exxonmobil Biomedical Sciences Inc., Annandale, NJ, USA;5. Shell Global Solutions US Inc., Houston, TX, USA;6. Office of Research & Development, US EPA, Gulf Breeze, FL, USA |
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| Abstract: | The purpose of this study was to compare enzymatic biomarker activities in fish caged at two sites, Masan Bay (contaminated) and Haeguemgang (reference). In the present study, ethoxyresorufin O-deethylase (EROD), brain acetyl cholinesterase (bAChE), muscle acetyl cholinesterase (mAChE) and butyryl cholinesterase (mBChE) in caged rockfish (Sebastes schlegeli) were measured 0, 1, 3, 7, 14, 21 and 30 days after caging. The level of CYP1A mRNA and Protein expression was induced higher in Masan Bay at 1, 3, 7, 14 and 30 days after caging. EROD activity in the caged fish was significantly higher in Masan Bay than in Haeguemgang 3 and 7 days after caging, but not at 14 and 30 days after caging. bAChE activity was significantly inhibited at 7 and 14 days after caging in Masan Bay. However, mBChE activity was not significantly inhibited during the experiment. Taken together, the data suggest that the caged fish were exposed, at least transiently, to CYP1A inducers and ChE inhibitors, which is consistent with our previous observations. |
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