Antithrombotic effects of bromophenol,an alga-derived thrombin inhibitor |
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| Authors: | SHI Dayong LI Xiaohong LI Jing GUO Shuju SU Hua FAN Xiao ? Institute of Oceanology Chinese Academy of Sciences Qingdao China Qingdao Municipal Hospital Qingdao China |
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| Institution: | SHI Dayong,LI Xiaohong,LI Jing,GUO Shuju,SU Hua,FAN Xiao ? Institute of Oceanology,Chinese Academy of Sciences,Qingdao 266071,China Qingdao Municipal Hospital,Qingdao 266011,China |
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| Abstract: | Thrombin,the ultimate proteinase of the coagulation cascade,is an attractive target for the treatment of a variety of cardiovascular diseases.A bromophenol derivative named (+)-3-(2,3-dibromo-4,5-dihydroxy-phenyl)-4-bromo-5,6-dihydroxy-1,3-dihydroiso-benzofuran 1,isolated from the brown alga Leathesia nana exhibited significant thrombin inhibitory activity.In this study,we investigated the inhibition of human thrombin in vitro with this bromophenol derivative,and its antithrombotic efficacy in vivo using th... |
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| Keywords: | thrombin inhibitor antithrombotic effect bromophenol derivative |
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