Biochemical and histological responses in mussel (Mytilus edulis) exposed to North Sea oil and to a mixture of North Sea oil and alkylphenols |
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| Authors: | N Aarab C Minier S Lemaire E Unruh P -D Hansen B K Larsen O -K Andersen J -F Narbonne |
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| Institution: | a Environmental and Toxicological Chemistry LPTC, UMR CNRS 5472, University of Bordeaux I, Talence, France;b Laboratory of Ecotoxicology LEMA, University of Le Havre, BP 540, 76058, Le Havre, France;c Technische Universitât Berlin, FB7-Institute for Ecological Research and Technology, Department of Ecotoxicology, Berlin, Germany;d RF-Rogaland Research, PO Box 2503, N-4091, Stavanger, Norway |
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| Abstract: | Several environmental chemicals are suspected to be responsible for adverse health effects on the reproductive system in various organisms. During this work, environmentally relevant concentrations of North Sea oil were used alone or in combination with alkylphenols and additional PAH to study the effect on vitellogenin-like protein expression and gonadal development in mussels. North Sea oil (0.5 ppm) induced the expression of phospho-proteins in both sexes indicating that some compounds are oestrogen-mimics. This induction was not seen in samples dosed with the mixture but signs of toxic effects were observed in the gonads. Indeed, numerous degenerating ovarian follicles in females and foci, similar to vertebrate melanomacrophage centres, were observed in testes. |
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| Keywords: | Mytilus edulis Vitellogenin-like protein Histopathology Endocrine disruption |
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