This paper proposes a semi-analytical solution of undrained cylindrical cavity expansion in anisotropic soils with both isotropic and frictional destructuration. The rigorous derivation based on the general form of the SANICLAY model with destructuration is provided following a standardized solving procedure, and the features of anisotropy and structuration are then invoked in the cavity expansion solution by adopting the non-associated hierarchical model. Cavity expansion tests in both structured and unstructured clays with various overconsolidation ratio are conducted to investigate the evolutions of effective stresses, excess pore pressure, anisotropic parameters and structuration factors during cylindrical expansion. The results show that the effective stresses at the cavity wall are lower after expansion and the cavity excess pore pressure is oppositely higher in structured clays with slightly smaller plastic regions. The evolutions of anisotropy for structured clays appear to follow similar patterns to unstructured cases, whereas the degree of anisotropy is further developed with gradual loss of inter-particle bonds. Finally, the proposed solution is applied to predict the limit pressure of pressuremeter tests in Bothkennar clay, showing its ability for interpretation of in situ testing data in natural structured clays.