Isolation,identification, and cytotoxicity of a new isobenzofuran derivative from marine <Emphasis Type="Italic">Streptomyces</Emphasis> sp. W007 |
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| Authors: | Hongyu Zhang Zeping Xie Tingting Lou Peng Jiang |
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| Institution: | 1.Tianjin Key Laboratory of Food Biotechnology, College of Biotechnology and Food Science,Tianjin University of Commerce,Tianjin,China;2.Key Laboratory of Experimental Marine Biology, Institute of Oceanology,Chinese Academy of Sciences,Qingdao,China;3.School of Pharmacy,Binzhou Medical University,Yantai,China;4.Tianjin Entry & Exit Inspection and Quarantine Bureau,Tianjin,China |
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| Abstract: | A new isobenzofuran derivative (1) was isolated from the marine Streptomyces sp. W007 and its structure was determined through extensive spectroscopic analyses, including 1D-NMR, 2D-NMR, and ESI-MS. The absolute configuration of compound 1 was determined by a combination of experimental analyses and comparison with reported data, including biogenetic reasoning, J-coupling analysis, NOESY, and 1H-1HCOSY. Compound 1 exhibited no cytotoxicity against human cells of gastric cancer BGC-823, lung cancer A549, and breast cancer MCF7. |
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