Investigation into the hemolytic activity of tentacle venom from jellyfish <Emphasis Type="Italic">Cyanea nozakii</Emphasis> Kishinouye |
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| Authors: | Cuiping Li Huahua Yu Rongfeng Li Ronge Xing Song Liu Pengcheng Li |
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| Institution: | 1.Key Laboratory of Experimental Marine Biology, Institute of Oceanology,Chinese Academy of Sciences,Qingdao,China;2.Qingdao University of Technology,Qingdao,China |
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| Abstract: | Cyanea nozakii Kishinouy e (C. nozakii), a giant cnidarian of the class Scyphomedusae, order Semaeostomeae and family Cyaneidae, is widely distributed in the East China Sea, the Yellow Sea and the Bohai Sea, and is abundant from late summer to early autumn. Venom produced by C. nozakii during mass agglomerations can contaminate seawater resulting in death of the halobios and seriously damage commercial fisheries. Swimmers and fishermen commonly suff er painful stings from this jellyfish, resulting in local edema, tingling, breathing difficulties, depressed blood pressure and even death. Such effects arise from the complex mixture of biologically active molecules that make up jellyfish venom. In the present study, the hemolytic activity of venom from tentacles of C. nozakii and factors aff ecting its activity were assayed. The HU50 ( defined as the amount of protein required to lyse 50 % of erythrocytes) of the venom against dove and chicken erythrocytes was 34 and 59 μg/mL, respectively. Carboxylmethyl chitosan and glycerol could increase hemolytic activity at concentrations greater than 0.06% and 0.2 mol/L, respectively. |
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