Effects of inhibitors on 1-methyladenine induced maturation of starfish oocytes |
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| Authors: | Harold H Lee Xu Quanhan |
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| Institution: | (1) University of Toledo, Ohio, USA;(2) Institute of Oceanology, Academia Sinica, Qingdao |
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| Abstract: | 1-methladenine (1-MA) induces starfish oocytes maturation via surface reaction followed by the appearance of a cytoplasmic
maturation factor which in turn induces germinal vesicle breakdown (GVBD) to resume meiosis. Cellular mechanisms involved
in GVBD were investigated by microinjection of metabolic inhibitors. Colchicine (Co) inhibited maturation, cytochalasin-B
(CB) delayed GVBD and actinomycin-D-(Act-D) and puromycin (Pu) had no effect. It appears that the microtubule and the microfilament
systems are associated with the nuclear membrane dissolution during the process of oocyte maturation of starfish. |
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