Characterisation of the Egyptian Pliocene bentonite from the Sohag region for pharmaceutical use |
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| Authors: | Abdelhamid Elshater Abdelaziz Elhaddad Attef Elattaar Magdy Abugharbia Waffa Soliman |
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| Institution: | 1.Geology Department, Faculty of Science,Sohag University,Sohag,Egypt;2.Botany Department, Faculty of Science,Sohag University,Sohag,Egypt |
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| Abstract: | This paper aims to prepare purified Na-bentonite with improved properties for its use in the pharmaceutical industry. Calcium bentonite from the Sohag region of Egypt was activated with various proportions of sodium carbonate (2, 3, 5 and 8 wt.%). Additionally, bentonite was purified by sedimentation to eliminate impurities, especially quartz. The results of X-ray diffraction (XRD) and swelling volume data confirmed that raw bentonite was converted to sodium bentonite using 5% Na2CO3. The sodium bentonite (M5) obtained by activation met the chemical and microbiological requirements set by the pharmacopoeias regarding toxic trace elemental contents (As, Pb and Cd), the absence of E. coli, the total contents of aerobic microbes and physicochemical properties such as swelling volume, pH and sedimentation volume. Therefore, (M5) bentonite can be designated as being potentially appropriate for pharmaceutical applications. The cation exchange capacity (CEC), surface area, porosity, pH, gel formation and swelling volume data indicated that M5 bentonite could be used to formulate oral suspensions and in topical application. |
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