Unbleached pulp mill effluents affect cytochrome P450 monooxygenase enzyme activities |
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| Authors: | Pirjo Lindstrm-Sepp Sirpa Huuskonen Maija Pesonen Paula Muona Osmo Hnninen |
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| Institution: | Pirjo Lindström-Seppä, Sirpa Huuskonen, Maija Pesonen, Paula Muona,Osmo Hänninen |
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| Abstract: | The polysubstrate monooxygenase system has been shown to be highly responsive to chemical pollution. The present study summarizes the enzyme based biomonitoring of the waste waters released by a pulp mill producing unbleached pulp and paperboard. Cytochrome P4501A enzyme activities of feral and caged fish, as well as cultures of fish hepatocytes, were tested. The 7-ethoxyresorufin-O-deethylase (EROD) activity was clearly induced in fish hepatocytes exposed to biotreated unbleached pulp mill effluent fractions in vitro. The effluent increased EROD activities also in feral perch, compared with controls. Caging experiments showed similar effects to those seen in feral fish: however, the maximal induction coefficients observed were higher. Unbleached effluents contain compounds that are able to affect the P4501A activities in fish. |
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