| 由定时引起的突触增强和抑制整合的数学模型 |
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| 引用本文： | 王怀阳,王朋朋.由定时引起的突触增强和抑制整合的数学模型[J].中国海洋大学学报(自然科学版),2006,36(5):712-714. |
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| 作者姓名： | 王怀阳 王朋朋 |
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| 作者单位： | 中国海洋大学电子工程系,山东,青岛,266071 |
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| 摘 要： | 由动作引起的突触变化对神经系统的生长和功能是十分重要的,其变化的程度和方向是由突触前后动作电位的精确定时引起的。通过对海马神经元中“三峰电位组激励”和“四峰电位组激励”范例的研究结果分析,得出描述突触前后多个峰电位相互作用的数学模型,即当前-后峰电位对出现在后-前峰电位对之前时,突触增强和抑制相互抵消;而当发生相反时序时,突触增强以指数的形式递减。
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| 关 键 词： | 峰电位定时 长时程增强 长时程抑制 |
| 文章编号： | 1672-5174(2006)05-712-03 |
| 收稿时间： | 2006-01-15 |
| 修稿时间： | 2006-06-05 |
A Mathematical Model for Timing-Dependent Integration of Synaptic Potentiation and Depression |
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| WANG Huai-Yang,WANG Peng-Peng.A Mathematical Model for Timing-Dependent Integration of Synaptic Potentiation and Depression[J].Periodical of Ocean University of China,2006,36(5):712-714. |
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| Authors: | WANG Huai-Yang WANG Peng-Peng |
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| Institution: | Department of Electronics Engineering, Ocean University of China, Qingdao 266071, China |
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| Abstract: | Activity dependent synaptic modification is critical for the development and function of nervous system,the extent and direction of modification may depend on the precise timing of pre-and post-synaptic action potentials.According to the results of triplet spiking paradigms and quadruplets spiking paradigms in the cultured hippocampal neurons,there was a mathematical model describing the coactivation of the complex spikes.When the pre-post spike pair appears before the post-pre pair,synaptic potentiation and depression seem to cancel;when they appear in the opposite timing,synaptic potentiation will decay exponentially. |
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| Keywords: | STDP |
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