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Induction of cytochrome p-450 monooxygenase activities in plaice by ‘model’ inducers and drilling muds |
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| Authors: | MJ Leaver MD Burke SG George JM Davies D Raffaelli |
| Abstract: | The hepatic cytochrome P-450-dependent monooxygenase system of the marine fish plaice has been characterised by i.p. injection with chemical inducing agents, followed by measurement of a variety of monooxygenase activities. The results suggest that more than one isozyme is present in these fish. The response to oil-based drilling fluids, a major contaminant of the North Sea, has also been examined and indicates that more than one isozyme is responsive to these products. |
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