Zige Tangco (4560 m a.s.l.), located in central Tibetan Plateau, was first discovered in China to be a meromictic lake. The meromixis was caused possibly by virtual sheltering due to the lake basin’s morphometry, and to a less extent by surface inflow of fresh water. As the highest meromictic lake ever discovered in the world, Zige Tangco could provide some insight into world lake systematic classification, and a potential site for present-day lake processes and lacustrine varve studies.