Properties of polysaccharides in several seaweeds from Atlantic Canada and their potential anti-influenza viral activities |
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| Authors: | Guangling Jiao Guangli Yu Wei Wang Xiaoliang Zhao Junzeng Zhang Stephen H Ewart |
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| Institution: | 1) Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, P. R. China 2) Shandong Provincial Key Laboratory of Glycoscience and Glycoengineering, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, P. R. China 3) National Research Council Canada-Institute for Marine Biosciences, Halifax, NS, B3H 3Z1, Canada 4) Laboratory of Molecular Pharmacology, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, P. R. China 5) National Research Council Canada-Institute for Nutrisciences and Health, Charlottetown, PEI, C1A 4P3, Canada |
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| Abstract: | To explore the polysaccharides from selected seaweeds of Atlantic Canada and to evaluate their potential anti-influenza virus
activities, polysaccharides were isolated from several Atlantic Canadian seaweeds, including three red algae (Polysiphonia lanosa, Furcellaria lumbricalis, and Palmaria palmata), two brown algae (Ascophyllum nodosum and Fucus vesiculosus), and one green alga (Ulva lactuca) by sequential extraction with cold water, hot water, and alkali solutions. These polysaccharides were analyzed for monosaccharide
composition and other general chemical properties, and they were evaluated for anti-influenza virus activities. Total sugar
contents in these polysaccharides ranged from 15.4% (in U. lactuca) to 91.4% (in F. lumbricalis); sulfation level was as high as 17.6% in a polysaccharide from U. lactuca, whereas it could not be detected in an alikali-extract from P. palmaria. For polysaccharides from red seaweeds, the main sugar units were sulfated galactans (agar or carrageenan) for P. lanosa, F. lumbricalis, and xylans for P. palmata. In brown seaweeds, the polysaccharides largely contained sulfated fucans, whereas the polysaccharides in green seaweed were
mainly composed of heteroglycuronans. Screening for antiviral activity against influenza A/PR/8/34 (H1N1) virus revealed that
brown algal polysaccharides were particularly effective. Seaweeds from Atlantic Canada are a good source of marine polysaccharides
with potential antiviral properties. |
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| Keywords: | polysaccharides anti-influenza viral activity monosaccharide composition H1N1 |
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