This paper deals with the region off the Maures and Estérel Massifs, the Provence calcareous ranges and the Alpine border (Figure 1). This portion of the Mediterranean continental margin has been investigated with the classical methods used in the geosciences: geophysics, geology, sedimentology, geochemistry.Many general studies are dealing with the Mediterranean and its tectonical history is still controversial. The relationship between the central zone (zone A) and the geologically well-known land massifs could help in understanding the structural framework. The present detailed study concerns the continental margin off Côte d'Azur. A relatively narrow continental shelf, a steep continental slope (10–20°) with collapsed continental blocks are defined by preliminary bathymetric studies with a spacing of one nautical mile. Many submarine canyons follow former faults which have been rejuvenated.A series of seismic reflection profiles (sparker and air-gun) provide limits for zone A (with many domes), allow tracing major faults and display important sedimentary and neotectonic processes (sliding, foundering). These profiles have been scaled with 50 cores. Evidence is brought forward for a local subsidence of over 1000 m. The deep structure has been investigated with marine magnetic methods. The results from seismic refraction, gravity and magnetics show a swell of the mantle beneath zone A, with a steep dipping of the M discontinuity under the margin, buried volcanoes south of Antibes and great faults striking NS or EW.These results seem to be important enough to propose a place in this zone of the Mediterranean as a JOIDES drilling site.