| 对PH敏感的顺磁性造影剂—Fe—EDTA |
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| 引用本文： | 许乙凯,刘杏元.对PH敏感的顺磁性造影剂—Fe—EDTA[J].CT理论与应用研究,1999,8(2):15-16. |
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| 作者姓名： | 许乙凯 刘杏元 |
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| 作者单位： | 广州第一军医大学南方医院影像中心造影剂研究室!510515 |
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| 摘 要： | 目的探讨ＰＨ值对Ｆｅ－ＥＤＴＡ造影效果的影响。方法；配制ＰＨ梯度５０－８０的０．５和０．１ｍｍｏｌ／Ｌ的Ｆｅ－ＥＤＴＡ液，观察ＳＥ序列「ＴＲ（ｍｓ）／ＴＥ（ｍｓ）２００／１５，２５００／８０」，信号变化，结果：Ｆｅ－ＥＤＴＡ的ＭＲ信号随ＰＨ值提高而减弱。
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| 关 键 词： | 造影剂 磁共振成像 铁 顺磁性造影剂 PH敏感 |
A Novel PH-Sensitive MR Contrast Agent-Fe-EDTA |
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| Xu Yikai and Liu Xingyuan.A Novel PH-Sensitive MR Contrast Agent-Fe-EDTA[J].Computerized Tomography Theory and Applications,1999,8(2):15-16. |
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| Authors: | Xu Yikai and Liu Xingyuan |
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| Abstract: | Purpose To invesitigate Fe-EDTA as a potential PH-sensitive 1H MR contrastagent .Methods Solutions of Fe-EDTA in a concentration of 1 .0 and 0.5mmol/L were prepared inphosphate bufferd isotonic saline The PH of the solutions was adjusted to specific values rangedfrom PH 5.0 to 8.0 Then,the effects of PH on MR intensity for the solution of Fe-EDTA wereobserved with 1.5 Tesla MR system using SE sequenceTR(ms)/TE(ms)200/15,2500/80],ResultsWith increasing the PH values. effect of paramagnetic enhancemert of Fe-EDTA was decreasedcorrespondigly,Conclusion The contrast effect of Fe-EDTA is closely PH-dependert. It may beuseful for early detection of local acid-base disturbance |
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| Keywords: | Contrast Agent Magnetic Resonance Imaging Iron |
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