Uptake and biological effects of synthetic glucocorticoids in common carp (Cyprinus carpio) |
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| Authors: | Kei Nakayama Yoshiyuki Inoue Naomi Ikeda Naoki Hashizume Hidekazu Murakami Takeshi Ishibashi Hirofumi Ikeda Tomohiko Isobe Shin-Ichi Kitamura Go Suzuki |
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| Institution: | 1. Center for Marine Environmental Studies (CMES), Ehime University, 2-5 Bunkyo-cho, Matsuyama 790-8577, Japan;2. Chemicals Evaluation and Research Institute, Japan, CERI Kurume, 3-2-7 Miyanojin, Kurume 839-0801, Japan;3. National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba 305-8506, Japan |
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| Abstract: | Uptake and biological effects of synthetic glucocorticoids (GCs) were analyzed using common carp (Cyprinus carpio). Fish were exposed to clobetasol propionate (CP) or clobetasone butyrate (CB) individually or in mixture at 1 μg L−1 for 21 days. Bioconcentration factor (BCF) of CB was calculated as 100, and BCF of CP was less than 16. No effects were found in fish erythrocyte and leukocyte numbers and serum glucose levels after exposure to the selected GCs. On the other hand, serum concentrations of free amino acids significantly increased in GC-exposed groups. Thus, exposures to synthetic GCs at relatively low concentrations seemed to cause enhancement of protein degradation and subsequent increase of serum free amino acids without a corresponding increase in serum glucose levels, an effect which might be related to partial induction of gluconeogenesis by GC. |
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| Keywords: | Glucocorticoid Common carp Bioconcentration factor Blood cell composition Glucose Free amino acid |
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