Effects of the modified Huanglian Jiedu decoction on the disease resistance in grey mullet (Mugil cephalus) to Lactococcus garvieae |
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| Authors: | WM Choi CL Lam WY Mo Z Cheng NK Mak ZX Bian MH Wong |
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| Institution: | 1. State Key Laboratory in Marine Pollution - Croucher Institute for Environmental Sciences, Hong Kong Baptist University and City University of Hong Kong, Hong Kong, PR China;2. Centre for Education in Environmental Sustainability and Department of Science and Environmental Studies, The Hong Kong Institute of Education, Hong Kong, PR China;3. School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, PR China |
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| Abstract: | Lactococcosis is prevalent on grey mullet (Mugil cephalus) in Hong Kong aquaculture resulting in serious economic loss. A compound formulation of Traditional Chinese Medicines (TCM) (modified Huanglian Jiedu decoction (HLJDD)) comprising Rhizoma coptidis, Radix scutellaria, Cortex phellodendri, Fructus gardeniae, Fructus forsythiae and Flos lonicerae japonicae (in a ratio of 3:2:2:3:3:5) were applied as feed supplements to deal with the disease. The Nitroblue tetrazolium activity in blood, bactericidal activity and total immunoglobulin in plasma were significantly enhanced after feeding 1% of this TCM for 28 days. The disease resistances to Lactococcus garvieae in 1% and 2% TCM feeding groups were significantly enhanced. In the in vitro study, the modified HLJDD also activated the plasma bactericidal activities (p < 0.01). Based on this study, 1% modified HLJDD feeding for 28 days may be an optimal dose to prevent L. garvieae infection and could be used in aquaculture industries. |
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| Keywords: | Traditional Chinese Medicine Lactococcus garvieae Grey mullet Bactericidal activity Aquaculture |
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