| Isolation and pharmacological activities of bromophenols from Rhodomela confervoides |
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| 作者姓名： | 韩丽君 徐年军 石建功 严小军 |
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| 作者单位： | [1]InstituteofOceanology,ChineseAcademyofSciences,Qingdao266071,China [2]instituteofMarinaMedica,ChineseAcademyofMedicalSciences,Beijing100050,China [3]KeyLaboratoryofMarineBiotechnology,NingboUniversity,Ningbo315211,China |
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| 基金项目： | Supported by National “863” Program (No. 2004AA625030, 2001AA620503), Qingdao marine sciences project (No. 04-2-NN-26) and Key Knowledge Innovative Project of the Chinese Academy of Sciences (KZCX3-SW-215). |
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| 摘 要： | Four bromophenols were isolated from the extract of marine red alga, Rhodomela confervoides by column chromatography and HPLC methods. By means of spectroscopic methods including IR, MS, 1D, and 2D-NMR techniques, their structures were elucidated as (1) 3-bromo-4,5-dihydroxy benzoic acid methyl ester; (2) his (2,3-dibromo-4,5-dihydroxybenzyl) ether; (3) 3,4-dibromo-5-(methoxymethyl)-1,2-benzenediol and (4)3-bromo-4,5-dihydroxy-benzaldehyde. Compound 1 was first isolated from the algae in nature, and 1, 4 were found to have selective cytotoxic activities against KB, Bel 7402 and A549 cells, 2 showed powerful antibacterial activities against Staphylococcus aurens and Pseudomonas aeruginosa.
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| 关 键 词： | 四溴苯酚 海洋红藻 抗菌药 药理学活性 |
Isolation and pharmacological activities of bromophenols from Rhodomela confervoides |
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| HAN Lijun,XU Nianjun,SHI Jiangong ?,YAN Xiaojun,ZENG Chengkui.Isolation and pharmacological activities of bromophenols from Rhodomela confervoides[J].Chinese Journal of Oceanology and Limnology,2005,23(2):226-229. |
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| Authors: | HAN Lijun XU Nianjun SHI Jiangong ? YAN Xiaojun ZENG Chengkui |
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| Abstract: | Four bromophenols were isolated from the extract of marine red alga, Rhodomela confervoides by column chromatography and HPLC methods. By means of spectroscopic methods including IR, MS, 1D, and 2D-NMR techniques, their structures were elucidated as (1) 3-bromo-4,5-dihydroxy benzoic acid methyl ester; (2) bis (2,3-dibromo-4,5-dihydroxybenzyl) ether; (3) 3,4-dibromo-5-(methoxymethyl)-1,2-benzenediol and (4) 3-bromo-4,5-dihydroxy-benzaldehyde. Compound 1 was first isolated from the algae in nature, and 1, 4 were found to have selective cytotoxic activities against KB, Bel 7402 and A549 cells, 2 showed powerful antibacterial activities against Staphylococcus aurens and Pseudomonas aeruginosa. |
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| Keywords: | Rhodomela confervoides bromophenol antitumor antibacterial |
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