| 地氟病属于"钙矛盾疾病" |
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| 引用本文： | 李广生,张文岚,华坤,李洪岩,徐辉.地氟病属于"钙矛盾疾病"[J].矿物岩石地球化学通报,2003,22(2):93-95. |
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| 作者姓名： | 李广生 张文岚 华坤 李洪岩 徐辉 |
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| 作者单位： | 吉林大学,地方病研究所,吉林,长春,130021 |
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| 基金项目： | 国家自然科学基金重点资助项目(39730390) |
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| 摘 要： | 膳食低钙是地氟病病区居民中的普遍现象，是地氟病(氟骨症)的主要促发和加重因素。低钙的作用不仅在于增如肠道氟的吸收，更在于它和过量氟同样都可引起甲状旁腺激素分泌增多，都可促进成骨、破骨功能活跃。过量氟可进一步加重机体缺钙。我们最近的研究证明，氟中毒大鼠肝、肾、脑组织Ca^2 ]i升高，培养的成骨细胞样细胞染氟后细胞内钙亦增加；即氟中毒存在着全身缺钙继而细胞内钙增多的钙矛盾现象，属于钙矛盾疾病。为控制和消除地氟病危害，应把减少氟的摄入和改善居民钙营养两结合起来。
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| 关 键 词： | 地氟病 膳食 缺钙 氟骨症 钙矛盾疾病 钙营养 |
| 文章编号： | 1007-2802(2003)02-0093-03 |
| 修稿时间： | 2002年12月28 |
Endemic Fluorosis Belongs to Calcium Paradox Disease |
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| LI Guang-sheng,ZHANG Wen-lan,HUA Kun,LI Hong-yan,XU Hui Institute of Endemic Disease,Jilin University,Changchun ,China.Endemic Fluorosis Belongs to Calcium Paradox Disease[J].Bulletin of Mineralogy Petrology and Geochemistry,2003,22(2):93-95. |
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| Authors: | LI Guang-sheng ZHANG Wen-lan HUA Kun LI Hong-yan XU Hui Institute of Endemic Disease Jilin University Changchun China |
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| Institution: | LI Guang-sheng,ZHANG Wen-lan,HUA Kun,LI Hong-yan,XU Hui Institute of Endemic Disease,Jilin University,Changchun 130021,China |
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| Abstract: | Dietary calcium deficiency, a prevalent phenomenon among the inhabitants in the endemic fluorosis areas, is a main provoking and aggravating factor of skeletal fluorosis. Low calcium plays roles not only in the increase of intestinal fluoride absorption and skeletal fluoride accumulation, but also in the stimulation of parathormone secretion and bone-forming and bone-resorbing activities, just the same as the role of excessive fluoride. Excessive fluoride further enhances calcium deficiency in the body. Our recent research data show a rise of Ca 2+ ] i in liver, kidney, and brain of fluorotic rats as well as in cultured osteoblast-like cells treated with fluoride. Since calcium deficiency followed by calcium excess is known as calcium paradox, we consider skeletal fluorosis to be an example of calcium paradox disease. For control and elimination of fluorosis, we should combine the reduction of fluoride intakes with the improvement of calcium nutrition. |
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| Keywords: | endemic fluorosis calcium deficiency calcium paradox |
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