| IN VITRO STUDY ON CYTOTOXIC EFFECTS OF THE ORGANOPHOSPHOROUS PESTICIDE PROFENOFOS ON THE GILL CELL LINE,FG-9307, OF THE FLOUNDER （PARALICHIHYS OLIVACEUS） |
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| 引用本文： | 李红岩,张士璀,姜明,汪岷.IN VITRO STUDY ON CYTOTOXIC EFFECTS OF THE ORGANOPHOSPHOROUS PESTICIDE PROFENOFOS ON THE GILL CELL LINE,FG-9307, OF THE FLOUNDER （PARALICHIHYS OLIVACEUS）[J].中国海洋与湖沼学报,2001,19(1):57-62. |
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| 作者姓名： | 李红岩 张士璀 姜明 汪岷 |
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| 作者单位： | DepartmentofMarineBiology,OceanUniversityofQingdao,Qingdao266003,China |
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| 摘 要： | The FG-9307 cell line derived from the gill of flounder Paralichthys olivaceus was used in the present study to determine the acute cytotoxic effects of the organophosphorous pesticide, profenofos. It was found that the cell growth rate was markedly reduced by profenofos at the concentrations of 2.5, 5 and 7.5 mg/L tested; and that the fine structures of the cells were also altered by profenofos, as evidenced by dilation of nuclear membranes and mitochondria cristae, and presence of enlarged lysoscrneswith engulfed organelles and numerous vacuoles in the cytoplama. Probably, mitochondria, the cell ener-gy-generating sites, are the most prcrninent sites of profenofos cytotoxity in the cells. This seems to be the first report of the use of marine fish cell line for evaluation of the acute in vitro cytotoxicity of organophos-phorus pesticide.
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| 关 键 词： | 有机磷 农药残留 电解槽 细胞毒素 海洋生态系统 海洋污染 |
| 收稿时间： | 13 September 1999 |
| 修稿时间： | 20 May 2000 |
In vitro study on cytotoxic effects of the organopho-sphorous pesticide profenofos on the gill cell line, FG-9307, of the flounder (Paralichihys olivaceus) |
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| Li Hong-yan,Zhang Shi-cui,Jiang Ming,Wang Min.In vitro study on cytotoxic effects of the organopho-sphorous pesticide profenofos on the gill cell line, FG-9307, of the flounder (Paralichihys olivaceus)[J].Chinese Journal of Oceanology and Limnology,2001,19(1):57-62. |
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| Authors: | Li Hong-yan Zhang Shi-cui Jiang Ming Wang Min |
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| Institution: | (1) Department of Marine Biology, Ocean University of Qingdao, 266003 Qingdao, China |
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| Abstract: | The FG-9007 cell line derived from the gill of flounderParalichthys olivaceus was used in the present study to determine the acute cytotoxic effects of the organophosphorous pesticide, profenofos. It
was found that the cell growth rate was markedly reduced by profenofos at the concentrations of 2.5, 5 and 7.5 mg/L tested;
and that the fine structures of the cells were also altered by profenofos, as evidenced by dilation of nuclear membranes and
mitochondria cristae, and presence of enlarged lysosomes with engulfed organelles and numerous vacuoles in the cytoplasm.
Probably, mitochondria, the cell energy-generating sites, are the most prominent sites of profenofos cytotoxity in the cells.
This seems to be the first report of the use of marine fish cell line for evaluation of the acute in vitro cytotoxicity of
organophosphorus pesticide.
This work was partially supported by the Marine 863 Project (No. 819-04-06). |
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| Keywords: | cytotoxicity profenofos flounder cell line |
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