| 动态增强磁共振成像在孤立性富血供肺结节良恶性鉴别诊断中的临床研究 |
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| 引用本文： | 李智勇,张婷婷,李梦颖,宋清伟,韩睿,伍建林.动态增强磁共振成像在孤立性富血供肺结节良恶性鉴别诊断中的临床研究[J].CT理论与应用研究,2012,21(3):563-570. |
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| 作者姓名： | 李智勇 张婷婷 李梦颖 宋清伟 韩睿 伍建林 |
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| 作者单位： | 大连医科大学附属第一医院放射科,辽宁大连,116011 |
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| 基金项目： | 2010年辽宁省科学技术计划项目“磁共振动态增强成像在肺癌靶向抗血管生成药物疗效评价的应用研究”(2010225034) |
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| 摘 要： | 目的：评价功能磁共振成像技术包括动态增强磁共振DCE-MR检查及其各种强化参数对肺内良、恶性结节鉴别诊断中的应用价值。方法：收集在2007年10月至2010年12期间行MR扫描且临床资料完整的孤立性肺结节病例55例,所有患者MRI检查包括常规MRI、DCE-MR。DCE-MR检查的主要测量参数包括,SIep、SImax...
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| 关 键 词： | 功能磁共振 肺癌 血管生成 |
Clinical Study of Dynamic Contrast-enhanced MR Imaging in Differential Diagnosis of Solitary Pulmonary Nodules with Abundant Blood Supply |
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| LI Zhl-yong,ZHANG Ting-ting,LI Meng-ying,SONG Qing-wei,HAN Rui,WU Jian-lin.Clinical Study of Dynamic Contrast-enhanced MR Imaging in Differential Diagnosis of Solitary Pulmonary Nodules with Abundant Blood Supply[J].Computerized Tomography Theory and Applications,2012,21(3):563-570. |
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| Authors: | LI Zhl-yong ZHANG Ting-ting LI Meng-ying SONG Qing-wei HAN Rui WU Jian-lin |
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| Institution: | Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China |
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| Abstract: | Objective： The aim of our study was to investigate the application value on dynamic contrast-enhanced MR （DCE-MR） imaging and its various enhanced parameters between benign and malignant pulmonary lesions. Methods： From 2007 October to 2010 December, fifty-five consecutive patients were prospectively enrolled in the study. All patients underwent DCE-MR imaging on a 1.5-T MR1 unit. Main measurement parameters of DCE-MR included signal intensity of early perk （SIep）, signal intensity of maximum perk （SImax）, signal intensity of end （SIen）, maximum enhance ratio （MER）, Slep%, ascending slope, descending slope and washout. Results： Various enhancement parameters of DCE-MR were analyzed to distinguish malignant and benign nodules with well blood supply. For DCE-MR, compared with various enhancement parameters of benign and malignant nodules with well blood supply, significant differences （P 〈 0.05） were observed in Slep, Slmax, SIen, MER and washout. And special significant differences （P 〈 0.01） were observed in SIep, Si and washout. Critical values of three parameters with P 〈 0.01 were selected and analyzed. When malignant nodules were diagnosed in the light of this condition, simultaneously conforming to SIep 〈 510, SImax 〈 550 and washout 〈 12, sensitivity, specifity, positive predictive value, negative predictive value, right index and diagnostic coincidence rate of its malignant diagnosis were 78.57%, 90%, 95.65%, 60%, 0.686, 81.58% respectively. Conclusion： DCE-MR could help for effective differential diagnosis between both nodules of hypervascularity, since it was very difficult for differesntial diagnosis in clinic. |
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| Keywords: | function MRI lung cancer angiogenesis |
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