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| 龙须菜和扁江篱多糖的组成及其抗肿瘤效果 | |
| 引用本文： | 邓志峰,纪明侯.龙须菜和扁江篱多糖的组成及其抗肿瘤效果[J].海洋与湖沼,1995,26(6):575-581. |
| 作者姓名： | 邓志峰 纪明侯 |
| 作者单位： | 中国科学院海洋研究所!青岛，266071，中国科学院海洋研究所!青岛，266071 |
| 摘 要： | 于１９８５－１９８７年期间用冷水和热水对采集于青岛的龙须菜和扁江篱的琼胶型多糖进行提取。两海藻的热水提取多糖都通过ＤＥＡＥ－ＳｅｐｈａｄｅｘＡ５０色谱桩用热水和不同浓度ＮａＣｌ深液前后进行洗脱分级。龙须菜和扁江篱多糖的主要级分分别为０．５ｍｏｌ／Ｌ和１．０ｍｏｌ／ＬＮａＣｌ洗脱级分。对各级分做化学分析及ＩＲ和＾１３ＣＮＭＲ光谱分析。结果表明，龙须菜多糖由琼二糖、琼胶糖前体和６－ＯＣＨ３－琼二糖组成 |
| 关 键 词： | 龙须菜 扁江篱 多糖 分级 海藻 抗钟瘤效果 |
| 收稿时间： | 1993/10/25 0:00:00 |
| 修稿时间： | 1994/7/10 0:00:00 |
COMPOSITION OF POLYSACCHARIDES OF GRACILARIA SJEOSTEDTII KYLIN AND G. TEXTORII (SUR.) De-Toni (RHODOPHYTA) AND THEIR i ANTITUMOR EFFECT |
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| Deng Zhifeng and Ji Minghou.COMPOSITION OF POLYSACCHARIDES OF GRACILARIA SJEOSTEDTII KYLIN AND G. TEXTORII (SUR.) De-Toni (RHODOPHYTA) AND THEIR i ANTITUMOR EFFECT[J].Oceanologia Et Limnologia Sinica,1995,26(6):575-581. |
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| Authors: | Deng Zhifeng and Ji Minghou |
| Institution: | Institute of Oceanology, Academia Sinica, Qingdao 266071;Institute of Oceanology, Academia Sinica, Qingdao 266071 |
| Abstract: | Two agar type polysaccharides were extracted with hot water and cold waterfrom Gracilaria s1eottedtii Kylin and G. tcxtorii (Sur.) De-Toni (Rhodophyta) col-lected on the seashore of Qingdao:from 1985 to 1987, and fractionated separatelyon DEAE-Sephadex A50 chromatographic column by elution with water and variousconcentration of NaCl solutions. The results showed that the main fraction fromG. sjeostedtii polysaccharide was 0.5 mol/L NaCl fraction, yielding 4l.3% of thetotal fraction, and that from G. textorii polysaccliaride was 1.0 mol/L NaCl frac-tion, yielding 33.6% of the total fraction. The eluted fractions were analyzed bychemical methods and by IR and 13C-NMR spectroscopic methods. It was clarifiedthat the main component of the O.5 mo1/L NaCl fraction from G- sieostedtii wasa mixture of agarose and precursor to agarose, while that of the 1.O mol/L fractionfrom G. textorii was a mixture of agarose, 6-OCH3-agarose and 6-OSO3-agarose.The polysaccharides and some fractions from botb species were,tested for their an-titumor effect against Sarcoma 180 in rats. The results indicated that the antitumorefficiencies of the polysaccharide extracted by cold water from G. sjeostedtii and ofthat extracted by hot water from G- textorii were 45% and 6O%, respective1y. Thesepolysaccharides would be promising' antitumor substances after further study throughanimal and clinical tests. |
| Keywords: | Gracilaraia sjeostedtii G textorii ~(13)C-NMR spectroscopic analysis Fraction Antitimor effect |
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