| 吲哚并喹啉类似物的合成及抗肿瘤活性评价 |
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| 引用本文： | 孟俊秀,万升标,任素梅,江涛.吲哚并喹啉类似物的合成及抗肿瘤活性评价[J].中国海洋大学学报(自然科学版),2011,41(11):91-94. |
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| 作者姓名： | 孟俊秀 万升标 任素梅 江涛 |
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| 作者单位： | 中国海洋大学医药学院,教育部海洋药物重点实验室,山东青岛266003 |
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| 基金项目： | 科技部国际科技合作项目-CMST(2008DFA31040)资助 |
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| 摘 要： | 建立了1种合成吲哚并喹啉羧酸化合物简便有效的方法。以邻氨基苯甲酸为起始原料,经酰化、缩合、环和、氯代、水解、还原多步反应得到6个吲哚并喹啉类似物。所合成化合物结构均经核磁共振及质谱技术验证,并利用MTT法测定了这6个吲哚并喹啉类似物对人乳腺癌细胞株MDA-231的体外扩增抑制活性。
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| 关 键 词： | 吲哚并喹啉类似物 抗肿瘤活性 合成 |
Synthesis and Antitumor Activity Evaluation of Quindoline Analogues |
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| MENG Jun-Xiu,WAN Sheng-Biao,JIANG Tao.Synthesis and Antitumor Activity Evaluation of Quindoline Analogues[J].Periodical of Ocean University of China,2011,41(11):91-94. |
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| Authors: | MENG Jun-Xiu WAN Sheng-Biao JIANG Tao |
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| Institution: | MENG Jun-Xiu,WAN Sheng-Biao,JIANG Tao(The Key Laboratory of Marine Drugs,Ministry of Education,College of Medicine and Pharmacy,Ocean University of China,Qingdao 266003,China) |
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| Abstract: | A facile method for a series of indoquinoline carboxylic acids was established.Six analogues of quindoline were synthesized using anthranllic acid as starting material via acylation,condensation,cyclization,chlorination,hydrolysis and hydrogenation.All synthesized compounds were confirmed by NMR and MS techniques.Proliferation inhibitory activity against the human breast cancer cell line(MDA 231) in vitro was investigated by using standard method of MTT. |
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| Keywords: | analogues of quindoline antitumor activity synthesis |
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