| 一种中国南海海绵Xestospongia testudinaria中化学成分的研究 |
| |
| 引用本文： | 孔雯雯,韩磊,李亮,邵长伦,章蓉,王长云.一种中国南海海绵Xestospongia testudinaria中化学成分的研究[J].中国海洋大学学报(自然科学版),2011,41(11):86-90. |
| |
| 作者姓名： | 孔雯雯 韩磊 李亮 邵长伦 章蓉 王长云 |
| |
| 作者单位： | 1. 中国海洋大学医药学院,海洋药物教育部重点实验室,山东青岛266003
2. Netherlands Centre for Biodiversity Naturalis, p.o.box 9517, 2300 ra leiden, Netherlands |
| |
| 基金项目： | 国家自然科学基金项目(40776073;30901879); 国家科技基础性工作专项(2007FY210500); 国家教育部高等学校博士学科点专项(20090132110002)资助 |
| |
| 摘 要： | 综合运用正相和反相硅胶柱层析、Sephadex LH-20凝胶柱层析以及制备HPLC等分离方法,从1种中国南海海绵Xestospongia testudinaria中追踪分离抗肿瘤活性次级代谢产物。从95%乙醇提取物中分离获得8个单体化合物,通过NMR,MS等波谱技术鉴定其结构分别为:E-18,18-二溴-9,17-二烯-5,7-二炔硬脂酸甲酯(1),E-18,18-二溴-9,17-二烯-5,7-二炔硬脂酸乙酯(2),麦角甾-5,7,22-三烯-3-醇(3),麦角甾-4,6,8(14),22-四烯-3-酮(4),胆甾-4-烯-3-酮(5),3-吲哚醛(6),3-吲哚酸(7)和5-吲哚醛(8)。其中,化合物2-5和8为首次从该属海绵中分离得到。化合物1对肿瘤细胞株HCT116和A549显示较强的抑制活性。
|
| 关 键 词： | 海绵 Xestospongia testudinaria 化学成分 分离 结构鉴定 |
Chemical Constituents of Sponge Xestospongia testudinaria from the South China Sea |
| |
| KONG Wen-Wen,HAN Lei,LI Liang,SHAO Chang-Lun,ZHANG Rong,Nicole J.de Voogd,WANG Chang-Yun.Chemical Constituents of Sponge Xestospongia testudinaria from the South China Sea[J].Periodical of Ocean University of China,2011,41(11):86-90. |
| |
| Authors: | KONG Wen-Wen HAN Lei LI Liang SHAO Chang-Lun ZHANG Rong Nicole Jde Voogd WANG Chang-Yun |
| |
| Institution: | KONG Wen-Wen1,HAN Lei1,LI Liang1,SHAO Chang-Lun1,ZHANG Rong1,Nicole J.de Voogd2,WANG Chang-Yun1(1.The Key Laboratory of Marine Drugs,Ministry of Education,School of Medicine and Pharmacy,Ocean University of China,Qingdao 266003,China,2.Netherlands Centre for Biodiversity Naturalis,p.o.box 9517,2300 ra leiden,the Netherlands) |
| |
| Abstract: | The chemical constituents of sponge Xestospongia testudinaria from the South China Sea were investigated by bioassay-guided fractionation.Eight compounds were isolated from 95% ethanolic extract by repeated column chromatography on silica gel and Sephadex LH-20,and preparative-HPLC.By means of spectroscopic data including NMR and MS,their structures were elucidated as E-9,17-octadecadiene-5,7-diynoic acid-18,18-dibromo-methyl ester(1),E-9,17-octadecadiene-5,7-diynoic acid-18,18-dibromo-ethyl ester(2),ergost... |
| |
| Keywords: | sponge Xestospongia testudinaria chemical constituents isolation structure elucidation |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
