| 海绵来源真菌Aspergillus sp BH4次级代谢产物的初步研究 |
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| 引用本文： | 方玉春,姜仁吉,朱天骄,张敏,朱伟明,顾谦群.海绵来源真菌Aspergillus sp BH4次级代谢产物的初步研究[J].中国海洋大学学报(自然科学版),2006,36(4):627-630. |
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| 作者姓名： | 方玉春 姜仁吉 朱天骄 张敏 朱伟明 顾谦群 |
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| 作者单位： | 中国海洋大学教育部海洋药物重点实验室,海洋药物与食品研究所,山东,青岛,266003 |
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| 摘 要： | 研究1株来源于海绵的真菌Aspergillus sp BH4的次级代谢产物，该菌的发酵产物具有细胞毒活性。采用硅胶柱色谱、制备薄层色谱及重结晶方法，对其活性组分一乙酸乙酯提取物的化学成分进行分离纯化，结合文献及NMR，MS波谱数据确定了4个单体化合物的结构。
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| 关 键 词： | 海绵真菌 次级代谢产物 结构鉴定 |
| 文章编号： | 1672-5174(2006)04-627-04 |
| 修稿时间： | 2005年12月20 |
Study on the Secondary Metabolites of Sponge-Associated Fungus, Aspergillus sp BH4 |
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| FANG Yu-Chun,JIANG Ren-Jie,ZHU Tian-Jiao,ZHANG Min,ZHU Wei-Ming,GU Qian-Qun.Study on the Secondary Metabolites of Sponge-Associated Fungus, Aspergillus sp BH4[J].Periodical of Ocean University of China,2006,36(4):627-630. |
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| Authors: | FANG Yu-Chun JIANG Ren-Jie ZHU Tian-Jiao ZHANG Min ZHU Wei-Ming GU Qian-Qun |
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| Abstract: | The secondary metabolites of the marine fungus Aspergillus sp BH4 derived from a sponge,were studied.The ethyl acetate extracts of the fermentation broth and mycelia showed cytotoxicity against Artemia salina.By means of repeated chromatography over silica gel,preparative TLC and recrystallization,4 compounds were isolated.And their structures were identified as ergosterol(1),1,4,5-trihydroxy-7-methoxy-2-methylanthracene-9,10-dione(2),2-(3,5-heptadienyl)-3,6-dihydroxy-5-(3-methyl-2-butenyl) benzaldehyde(3),and 2-(1-heptenyl)-3,6-dihydroxy-5-(3-methyl-2-butenyl) benzaldehyde(4),by spectroscopic method including 1D,2D NMR and MS. |
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| Keywords: | fungus derived from sponge secondary metabolites structure determination |
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