| 一种南海鼠尾藻次级代谢产物及其克生活性研究 |
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| 引用本文： | 金京,邵长伦,崔怡迪,管华诗,魏玉西,王长云.一种南海鼠尾藻次级代谢产物及其克生活性研究[J].中国海洋大学学报(自然科学版),2011(Z1):369-373. |
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| 作者姓名： | 金京 邵长伦 崔怡迪 管华诗 魏玉西 王长云 |
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| 作者单位： | 中国海洋大学医药学院海洋药物教育部重点实验室;青岛大学生物系; |
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| 基金项目： | 国家科技基础性工作专项(2007FY210500); 国家海洋局“908”专项(908-01-ST12908-02-05-04); 国家自然科学基金(30572314)资助 |
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| 摘 要： | 在卤虫致死活性的指导下,综合运用正、反相硅胶柱层析,Sephadex LH-20凝胶柱层析,制备HPLC等分离技术,对褐藻马尾藻属鼠尾藻Sargassumthunbergii进行了克生活性次级代谢产物研究。从鼠尾藻乙醇提取物的乙酸乙酯相中分离获得11个单体化合物,运用NMR,MS,IR等波谱技术鉴定了结构,分别为:2-(3S,7S,11S)-3-hydroxy-3,7,11,15-tetramethylhexadecyl]-3,5,6-tri methylcyclohexa-2,5-diene-1,4-dione(1),5-脱氢豆甾醇(2),盐藻甾醇(3),马尾藻甾醇(4),盐藻甾酮(5),过氧化麦角甾醇(6),1-(hexadecy1oxy)-propane-2,3-diol(7),1-(15-methylheptadecy1oxy)-propane-2,3-diol(8),3,7,11,15-tetramethyl-hexadecane-1-ol(9),植醇(10),3-(1-oxohexadecyl)oxy]-2-(9Z,12Z)-1-oxo-9,12-oc-tadecadien-1-yl]oxy]propyl(11)。其中,除化合物10外均为首次从马尾藻属中分离得到。对化合物进行了卤虫致死活性和斑马鱼胚胎毒性评价,结果显示,化合物1,5和6具有中等强度的卤虫致死活性;化合物6具有中等的斑马鱼胚胎毒性,EC50值为21.7μg/mL。
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| 关 键 词： | 鼠尾藻 次级代谢产物 结构鉴定 克生活性 |
The Secondary Metabolites from Sargassum thunbergii from the South China Sea and Their Allelopathic Activity |
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| JIN Jing,SHAO Chang-Lun,CUI Yi-Di,GUAN Hua-Shi,WEI Yu-Xi,WANG Chang-Yun.The Secondary Metabolites from Sargassum thunbergii from the South China Sea and Their Allelopathic Activity[J].Periodical of Ocean University of China,2011(Z1):369-373. |
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| Authors: | JIN Jing SHAO Chang-Lun CUI Yi-Di GUAN Hua-Shi WEI Yu-Xi WANG Chang-Yun |
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| Institution: | JIN Jing1,SHAO Chang-Lun1,CUI Yi-Di1,GUAN Hua-Shi1,WEI Yu-Xi1,WANG Chang-Yun1(1.Key Laboratory of Marine Drugs,Ministry of Education,School of Medicine and Pharmacy,Ocean University of China,Qingdao 266003,China,2.Department of Biology,Qingdao University,Qingdao 266071,China) |
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| Abstract: | Under the guidance of the lethal activities toward brine shrimp Artemia salina,eleven secondary metabolites were isolated from the EtOAc extracts of brown alga Sargassum thunbergii by column chromatography on Silica gel,Sephadex LH-20 and ODS,and preparative HPLC.Their structures were elucidated by spectroscopic analysis(NMR,MS,IR) as well as comparing with the data of literatures as: 2-(3S,7S,11S)-3-hydroxy-3,7,11,15-tetramethylhexadecyl]-3,5,6-trimethylcyclohexa-2,5-diene-1,4-dione(1),stigmast-5-en-3-ol(... |
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| Keywords: | Sargassum thunbergii secondary metabolities structural identification allelopathic activity |
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