| 鲣鱼肝脏酶解物对高果糖大鼠的降压活性研究 |
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| 引用本文： | 王玉明,武晓琳,李兆杰,薛勇,王静凤,薛长湖.鲣鱼肝脏酶解物对高果糖大鼠的降压活性研究[J].中国海洋大学学报(自然科学版),2011(Z1):61-64,70. |
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| 作者姓名： | 王玉明 武晓琳 李兆杰 薛勇 王静凤 薛长湖 |
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| 作者单位： | 中国海洋大学食品科学与工程学院; |
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| 基金项目： | 十一五科技支撑计划项目(2008BAD94B01)资助 |
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| 摘 要： | 研究鲣鱼肝脏酶解物对大鼠血压的影响,提高低值水产品加工副产物的利用价值。SD大鼠按体重和血压随机分为3组,每组7只。用高果糖饲料饲喂SD大鼠,建立高血压大鼠模型,实验组大鼠饲料中添加5%鲣鱼肝脏酶解物(KPLH),分别于第2周和第4周时测定清醒状态下大鼠尾动脉收缩压。喂食4周后腹主动脉采取全血,分离血清,试剂盒测定大鼠血脂、血糖、血清脂联素、瘦素和胰岛素浓度。KPLH摄食2周后大鼠血压较模型组降低9%(P<0.05),4周后KPLH摄食大鼠血压较模型组降低15%(P<0.05)。KPLH摄食显著提高血液中脂联素浓度(169%,P<0.01),胰岛素抵抗指数(HOMA-IR)恢复至正常水平(P<0.01),大鼠胰岛素抵抗性得到明显改善。血清脂联素浓度与血压之间的相关性解析表明,KPLH引起的血压升高抑制作用与脂联素升高有显著的相关性。KPLH可改善大鼠胰岛素抵抗性,提高血液中脂联素浓度,具有抑制血压升高的作用。
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| 关 键 词： | 鲣鱼 肝脏酶解物 果糖 高血压 脂联素 瘦素 胰岛素 |
The Hypotensive Activity of the Enzymatic Hydrolyte of Katsuwonus pelamis Liver in High-Fructose Fed Rats |
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| WANG Yu-Ming,WU Xiao-Lin,LI Zhao-Jie,XUE Yong,WANG Jing-Feng,XUE Chang-Hu.The Hypotensive Activity of the Enzymatic Hydrolyte of Katsuwonus pelamis Liver in High-Fructose Fed Rats[J].Periodical of Ocean University of China,2011(Z1):61-64,70. |
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| Authors: | WANG Yu-Ming WU Xiao-Lin LI Zhao-Jie XUE Yong WANG Jing-Feng XUE Chang-Hu |
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| Institution: | WANG Yu-Ming,WU Xiao-Lin,LI Zhao-Jie,XUE Yong,WANG Jing-Feng,XUE Chang-Hu(College of Food Science and Engineering,Ocean University of China,Qingdao 266003,China) |
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| Abstract: | In order to study the effects of the enzymatic hydrolyte of Katsuwonus pelamis liver(KPLH) on blood pressure in rats,twenty-one male SD rats were randomly divided into 3 groups according to body weight and blood pressure.Rats were fed on normal diet,high fructose basic diet or 5% KPLH containing high fructose basic diet.After 2 weeks and 4 weeks,systolic arterial pressure was measured.Serum lipids,glucose,adiponectin,leptin and insulin levels were determined after 4 weeks.KPLH feeding significantly reduced ... |
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| Keywords: | Katsuwonus pelamis liver hydrolyte fructose blood pressure adiponectin leptin insulin |
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