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孔雀石绿的代谢机理及生物毒性研究进展
引用本文:翟毓秀,郭莹莹,耿霞,张翠,宁劲松.孔雀石绿的代谢机理及生物毒性研究进展[J].中国海洋大学学报(自然科学版),2007,37(1):27-32.
作者姓名:翟毓秀  郭莹莹  耿霞  张翠  宁劲松
作者单位:1. 农业部海洋渔业资源可持续利用重点开放实验室,中国水产科学研究院黄海水产研究所,山东,青岛,266071;国家水产品质量监督检验中心,山东,青岛,266071
2. 农业部海洋渔业资源可持续利用重点开放实验室,中国水产科学研究院黄海水产研究所,山东,青岛,266071;中国海洋大学,水产品安全实验室,山东,青岛,266003
基金项目:科技部科技基础条件平台建设计划;科技部科技基础条件平台建设计划
摘    要:孔雀石绿(Malachite green,MG)是1种三苯甲烷类工业染料,曾广泛用于治疗水产动物的水霉病、烂鳃病、寄生虫病等,但由于具有高毒、高残留、“三致”等毒性性质,许多国家禁止其在经济鱼类(观赏鱼除外)的养殖过程中使用,成为药物残留监控的主要内容之一。本文对孔雀石绿的化学性质、代谢规律及机理、生物毒性等研究现状进行了综述,旨在为药残的监控工作提供理论依据。

关 键 词:孔雀石绿  无色孔雀石绿  代谢  生物毒性
文章编号:1672-5174(2007)01-027-06
修稿时间:2006-09-19

Advances in Studies on Metabolic Mechanism and Bio-Toxicity of Malachite Green
ZHAI Yu-Xiu,GUO Ying-Ying,GENG Xia,ZHANG Cui,NING Jin-Song.Advances in Studies on Metabolic Mechanism and Bio-Toxicity of Malachite Green[J].Periodical of Ocean University of China,2007,37(1):27-32.
Authors:ZHAI Yu-Xiu  GUO Ying-Ying  GENG Xia  ZHANG Cui  NING Jin-Song
Institution:1. Key Laboratory for Sustainable Utilization of Marine Fisheries Resources, Ministry of Agrieulture; Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China; 2. National Center for Quality Supervision and Test of Aquatic Products, Qingdao 266071, China; 3. Seafood Safety Laboratory, Ocean University of China, Qingdao 266003, China
Abstract:Malachite green is an N-methylated diaminotriphenylmethane industrial dye,widely used as a strong antifungal,antibacterial,antiparasitical agent in the aquaculture industry.However,Malachite green is not approved for use in commercial fishes except for spectacular fishes in many countries,due to its high residue,high toxicity,carcinogenicity,teratogenicity,mutagenesis and so on.It is one of the key items in drug residual monitoring.This review summarizes the characteristics of malachite green and leucomalachite green,their metabolic laws and mechanisms,toxicological effects on various fish species and certain mammals.It can be of value for further monitoring of illegal use of drugs and drug residues.
Keywords:malachite green  leucomalachite green  metabolism  bio-toxicity
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