| 虾夷扇贝毒素yessotoxins(YTXs),中国沿海贝类中首次发现的一组贝类生物毒素 |
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| 引用本文： | 高春蕾,刘仁沿,梁玉波,王宗灵,刘永健,庞敏,张芳,潘宁,许道艳,邵魁双.虾夷扇贝毒素yessotoxins(YTXs),中国沿海贝类中首次发现的一组贝类生物毒素[J].海洋学报,2010,32(3):129-137. |
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| 作者姓名： | 高春蕾 刘仁沿 梁玉波 王宗灵 刘永健 庞敏 张芳 潘宁 许道艳 邵魁双 |
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| 作者单位： | 1.国家海洋局 第一海洋研究所 生态中心,山东 青岛 266061 |
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| 基金项目： | 国家专项"赤潮、海洋病原生物和外来生物入侵灾害调查与研究"(908-01-ZH3);国际合作项目"海产品质量安全保障关键技术研究"(2007FAD07030);国家基金"我国沿岸海域腹泻性贝毒化学组分结构与分布规律研究"(40876055)。 |
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| 摘 要： | 采用高效液相色谱-串联质谱方法对我国近海贝类中腹泻性贝毒成分进行研究,结果发现采自北黄海大连附近海域的海湾扇贝和虾夷扇贝含有25~41μg/kg的虾夷扇贝毒素(yessotoxin,YTX),在虾夷扇贝体内还含有37.2μg/kg的45-OH-YTX,并在5种贝中发现微量的Homo-YTX毒素组分,这是首次报道在我国贝中检出此类毒素。虾夷扇贝毒素YTXs是一类含有2个磺酰基的脂溶性多环聚醚类化合物,对小鼠的腹腔注射急性致死毒性很高,毒理作用机制尚不清楚。本研究的结果说明我国贝类体内生物毒素成分复杂,亟需进行毒素成分结构、来源生物、生态毒理效应、分布规律及安全限定标准的研究。
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| 关 键 词： | 虾夷扇贝毒素(yessotoxins) 腹泻性贝毒 高效液相色谱-串联质谱 贝类 |
| 收稿时间： | 2009/8/24 0:00:00 |
| 修稿时间： | 2009/11/24 0:00:00 |
First report of the presence of yessotoxins (YTXs) in shellfish from China's coastal areas |
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| GAO Chun-lei,LIU Ren-yan,LIANG Yu-bo,WANG Zong-ling,LIU Yong-jian,PANG Min,ZHANG Fang,PAN Ning,XU Dao-yan and SHAO Kui-shuang.First report of the presence of yessotoxins (YTXs) in shellfish from China's coastal areas[J].Acta Oceanologica Sinica (in Chinese),2010,32(3):129-137. |
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| Authors: | GAO Chun-lei LIU Ren-yan LIANG Yu-bo WANG Zong-ling LIU Yong-jian PANG Min ZHANG Fang PAN Ning XU Dao-yan and SHAO Kui-shuang |
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| Institution: | 1.First Institute of Oceanography, State Oceanic Administration,Qingdao 266061,China2.National Marine Environmental Monitoring Center, State Oceanic Administration, Dalian 116023, China |
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| Abstract: | The profile of diarrhetic shellfish poisoning (DSP) toxins in shellfish samples collected from Chinas coastal areas was analyzed with liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) analysis. The results of LC-MS/MS analysis show that Patinopecten yessoensis and Argopecten irradians collected from the northern Huanghai Sea contain YTX and 45-OH-homo-YTX. Furthermore, Homo-YTX, with very low levels (less than LOQ) was also detected in five shellfish species.This is the first report of the presence of yessotoxins (YTXs) in shellfish from Chinas coastal areas. YTXs are disulfated polyether marine toxins with a characteristic rapid death in the intraperitoneal mouse bioassay, but detailed information on the mechanism(s) of toxic action is not available. These results indicate that biotoxin contamination of shellfish in Chinas coastal areas are very complicated, it is very urgent to carry out researches in our country on toxin structures, biological origin(s), toxicological properties, ecological effects, distribution characteristics and maximum permitted levels. |
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| Keywords: | yessotoxins diarrhetic shellfish poisoning toxins liquid chromatography-mass spectrometry-mass spectrometry (LC-MS/MS) shellfish |
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