| 柳珊瑚Leptogorgia rigida中甾体类成分研究 |
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| 引用本文： | 肖细姬,邓芸,谢路凤,张琪,韦霞,于鑫,张翠仙.柳珊瑚Leptogorgia rigida中甾体类成分研究[J].热带海洋学报,2019,38(4):64-69. |
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| 作者姓名： | 肖细姬 邓芸 谢路凤 张琪 韦霞 于鑫 张翠仙 |
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| 作者单位： | 广州中医药大学中药学院, 广东 广州510006 |
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| 基金项目： | 国家自然科学基金项目((81741160););广东省科技计划((2015A020216017, 2017A020217008););广州中医药大学“薪火计划”重点项目((XH20170110););海南大学南海海洋资源利用国家重点实验室开放课题((2016003););广东省自然科学基金项目((2014A030313411).) |
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| 摘 要： | 首次对南海柳珊瑚Leptogorgia rigida中甾体类次生代谢产物进行研究。采用硅胶柱柱层析、十八烷基硅烷键合硅胶填料、Sephadex LH-20、高效液相色谱(HPLC)及薄层色谱(TLC)等多种方法进行分离纯化, 通过核磁共振波谱(NMR)、质谱(MS)等现代波谱分析及物理常数对照等方法进行结构鉴定。从南海柳珊瑚Leptogorgia rigida次生代谢产物中分离得到8个甾类化合物, 结构依次为: 3β, 6β, 11-trihydroxy-9, 11-seco-5α-chloest-7-en-9-one (1); 3β, 6α, 11- trihydroxy-9, 11-seco-5α-chloest-7-en-9-one (2); 3β, 6α, 11-trihydroxy-5α-chloest-7, 22(E)-dien-9-one (3); pregnan-4-en-3, 20-dione (4); 5α-pregnan-3, 20-dione (5); 3β-hydroxy-pregnan-5-en-20-dion (6); 3β-hydroxy-5α-pregnan-20-one (7); 和3β, 6α, 11-trihydroxy-9, 11-seco-5α-gorgosterol (8)。所有化合物均首次从Leptogorgia属中得到。
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| 关 键 词： | 南海柳珊瑚Leptogorgia rigida 甾类化合物 断甾醇 结构鉴定 |
| 收稿时间： | 2018-11-21 |
| 修稿时间： | 2019-01-04 |
Research on Sterols from Leptogorgia rigida |
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| Xiji XIAO,Yun DENG,Lufeng XIE,Qi ZHANG,Xia WEI,Xin YU,Cuixian ZHANG.Research on Sterols from Leptogorgia rigida[J].Journal of Tropical Oceanography,2019,38(4):64-69. |
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| Authors: | Xiji XIAO Yun DENG Lufeng XIE Qi ZHANG Xia WEI Xin YU Cuixian ZHANG |
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| Institution: | School of Pharmaceutical Science, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China |
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| Abstract: | Research was carried out on novel secondary metabolites from Leptogorgia rigida collected from the South China Sea. The secondary metabolites were isolated by silica gel column chromatography, ODS, Sephadex LH-20, thin layer chromatography, and high performance liquid chromatography (HPLC). The structures of compounds were identified by nuclear magnetic resonance spectrum (NMR), mass spectrum (MS), and literature analysis. Eight sterols were obtained and elucidated as follows: 3β, 6β, 11-trihydroxy-24-methyl-5α-chloest-9, 11-seco-7-en-9-one (1); 3β, 6α, 11-trihydroxy-24- methyl-5α-chloest-9, 11-seco-7-en-9-one (2); 3β, 6α, 11-tri- hydroxy-5α-chloest-9, 11-seco-7, 22(E)- dien-9-one (3); pregnan- 4-en-3, 20-dione (4); 5α-pregnan-3, 20-dione (5); 3β-hydroxy- pregnan-5-en-20-dione (6); 3β-hydroxy-5α-pregnan-20-one (7); and Gorgosterol (8). All the sterols were first obtained from Leptogorgia rigida. |
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| Keywords: | Leptogorgia rigida secondary metabolites secosterols identification |
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