| 壳聚糖的脱乙酰度、分子质量和性状对其体外促凝血活性的影响 |
| |
| 引用本文： | 程沁园,张家骊,夏文水.壳聚糖的脱乙酰度、分子质量和性状对其体外促凝血活性的影响[J].海洋科学,2012,36(6):59-63. |
| |
| 作者姓名： | 程沁园 张家骊 夏文水 |
| |
| 作者单位： | 1. 食品科学与技术国家重点实验室,江南大学食品学院,江苏无锡214122
2. 江南大学医药学院,江苏无锡214122 |
| |
| 基金项目： | 国家863 计划项目(2007AA091603); 食品科学与技术国家重点实验室2008 年目标导向项目(SKLF-MB-200805); PCSIRT0627;111 project-B07029 |
| |
| 摘 要： | 制备不同脱乙酰度、分子质量的壳聚糖固体粉末和溶液,并利用试管法比较了不同浓度、不同性质及不同状态的样品的体外凝血时间.结果表明:当分子质量相近时,壳聚糖溶液的体外凝血时间随脱乙酰度的增加而减少,脱乙酰度中等的固体粉末具有最强的促凝血能力;当脱乙酰度相近时,只有高分子质量的壳聚糖溶液具有一定的促凝血活性,但固体粉末状态的三种壳聚糖均具有一定的缩短体外凝血时间的能力;同等剂量的壳聚糖溶液和粉末,除了高脱乙酰度、高分子质量的壳聚糖外,其余样品的固体粉末对于缩短体外凝血时间更为有效
|
| 关 键 词： | 壳聚糖 粉末 溶液 促凝血活性 |
| 收稿时间： | 2011/5/19 0:00:00 |
| 修稿时间： | 2011/12/4 0:00:00 |
The effects of degrees of deacetylation, molecular weights and states of chitosans on procoagulant activities in vitro |
| |
| CHENG Qin-yuan,ZHANG Jia-li,XIA Wen-shui.The effects of degrees of deacetylation, molecular weights and states of chitosans on procoagulant activities in vitro[J].Marine Sciences,2012,36(6):59-63. |
| |
| Authors: | CHENG Qin-yuan ZHANG Jia-li XIA Wen-shui |
| |
| Institution: | 1(1.Key Laboratory of Food Science and Technology,Jiangnan University,1800 Lihu Avenue,Wuxi 214122;2.School of Medicine and Pharmaceutics,Jiangnan University,1800 Lihu Avenue,Wuxi 214122) |
| |
| Abstract: | To investigate the effects of degrees of deacetylation, molecular weights and states (solutions or solid powder) of chitosans on the procoagulant activities in vitro, the blood clotting time of the samples with different concentrations, properties and states were tested the in tube method. When molecular weights were close, the blood clotting time of chitosan solutions decreased with the increasing of degree of deacetylation, however, the procoaglant ability of the chitosan powder with medium degree of deacetylation was the best of all. When degrees of deacetylation were close, the solution of chitosan with high molecular weight was the only one that had procoagulant activity, but all the powders could decrease the clotting time in vitro. All solid chitosan powders, except the one with high degree of deacetylation and molecular weight, promoted the blood coaglations more efficiently than the correspondent solution at the same concentration. |
| |
| Keywords: | chitosan powder solution procoagulant activity |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《海洋科学》浏览原始摘要信息 |
| 点击此处可从《海洋科学》下载免费的PDF全文 |
|
