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| MALDI-TOF质谱技术研究胰岛素海藻酸钠纳米粒特性 | |
| 引用本文： | 曾新华,谢 麟,卓慧钦,黄河宁,林庆梅,易瑞灶,黄河清.MALDI-TOF质谱技术研究胰岛素海藻酸钠纳米粒特性[J].海洋科学,2006,30(1):73-77. |
| 作者姓名： | 曾新华 谢 麟 卓慧钦 黄河宁 林庆梅 易瑞灶 黄河清 |
| 作者单位： | 1. 厦门大学,生命科学学院,福建省化学生物学重点实验室,环境科学研究中心,福建,厦门,361005 2. 三明学院,化学与生物工程系,福建,三明,365000 3. 国家海洋局,第三海洋研究所,福建,厦门,361005 |
| 基金项目： | 国家自然科学基金资助项目(0402760633)，福建省自然科学基金资助项目(C0310006) |
| 摘 要： | 从海洋生物中提取海藻酸纳和壳聚糖作为纳米粒的包被材料,并分别包装成人胰岛素纳米粒。选用基质辅助激光解吸离子化飞行时间(Matrix-assistedlaserdesorptionionization/timeofflight,MALDI-TOF)质谱技术研究胰岛素海藻酸钠纳米粒包装、释放过程及在不同酸碱介质条件下的稳定性。 |
| 关 键 词： | MALDI-TOF 质谱 胰岛素 纳米粒包装 稳定性 |
| 文章编号： | 1000-3096（2006）01-0073-05 |
| 收稿时间： | 2003-07-21 |
| 修稿时间： | 2004-06-30 |
Studies on characteristics of sodium alginate nanoparticles of the insulin by MALDI-TOF mass spectrometry |
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| ZENG Xin-Hua,XIE Lin,ZHUO Hui-qin,HUANG He-ning,LIN Qing-mei,YI Rui-zao,HUANG He-qing.Studies on characteristics of sodium alginate nanoparticles of the insulin by MALDI-TOF mass spectrometry[J].Marine Sciences,2006,30(1):73-77. | |
| Authors: | ZENG Xin-Hua XIE Lin ZHUO Hui-qin HUANG He-ning LIN Qing-mei YI Rui-zao HUANG He-qing |
| Institution: | 1 .School of Life Sciences, The Center for Environmental Science Research, Xiamen University ,Xiamen 361005,China; 2.Department of Chemical and Biological Engineering, Sanming College, Sanming 365000,China; 3.Third Institute of Oceanography, State Oceanic Administration, Xiamen 361005,China |
| Abstract: | Sodium alginate and chitosan extracted from the halobios were selected as packaging materials of nanoparticles of the human insulin nanoparticles, respectively. Matrix-assisted laser desorption ionization /time of flight (MALDI-TOF) mass spectrometry was used to study the processes of packaging and releasing of the insulin and its stability in the different basic and acidic mediums from the sodium alginate nanoparticles . |
| Keywords: | MALDI-TOF mass spectrometry insulin nanoparticle stability |
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