| 苯酰胺类化合物防污活性基团的初步探索 |
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| 引用本文： | 荀靖懿,郑纪勇,程旭东,马力,张宏泉,蔺存国.苯酰胺类化合物防污活性基团的初步探索[J].海洋科学,2022,46(5):104-114. |
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| 作者姓名： | 荀靖懿 郑纪勇 程旭东 马力 张宏泉 蔺存国 |
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| 作者单位： | 武汉理工大学,中国船舶重工集团公司第七二五研究所 海洋腐蚀与防护国防科技重点实验室,武汉理工大学,中国船舶重工集团公司第七二五研究所 海洋腐蚀与防护国防科技重点实验室,武汉理工大学,中国船舶重工集团公司第七二五研究所 海洋腐蚀与防护国防科技重点实验室 |
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| 基金项目： | 国家自然科学基金(U2141251) |
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| 摘 要： | 开发绿色环保防污剂是海洋船舶防污涂料研究的重要方向，查明防污活性化合物分子结构中的防污活性基团，是设计开发新型防污剂的关键。本文合成了三种结构相似的苯酰胺类化合物HNOB、DOLPA和DHNOB，通过FTIR，1H NMR，13C NMR测试表征三种化合物的分子结构，利用典型污损生物硅藻和贻贝作为目标生物，测试其对硅藻和贻贝附着的影响，并将分子结构与防污活性进行对比，初步探讨影响防污性能的活性基团。硅藻和贻贝附着实验均表明，HNOB的防污性能较好，半数抑制浓度远低于DOLPA和DHNOB。通过结构对比分析发现，极性和非极性结构的协同作用比单一的极性基团或非极性长碳链基团能更好地赋予苯酰胺类物质良好的防污性能。该研究初步探讨了苯酰胺类化合物的构效关系，有助于新型防污活性化合物的设计开发和结构优化，并对探究该类化合物防除污损生物附着的机理和快速筛选有潜力的防污化合物具有重要意义。
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| 关 键 词： | 苯酰胺类化合物 硅藻附着 防污 构效关系 |
| 收稿时间： | 2021/12/24 0:00:00 |
| 修稿时间： | 2022/1/25 0:00:00 |
Preliminary study of the antifouling active groups of benza-mide compounds |
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| XUN Jing-yi,ZHENG Ji-yong,CHENG Xu-dong,MA Li,ZHANG Hong-quan,LIN Cun-guo.Preliminary study of the antifouling active groups of benza-mide compounds[J].Marine Sciences,2022,46(5):104-114. |
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| Authors: | XUN Jing-yi ZHENG Ji-yong CHENG Xu-dong MA Li ZHANG Hong-quan LIN Cun-guo |
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| Institution: | Wuhan University of Technology,State Key Laboratory for Marine Corrosion and Protection,Luoyang Ship Material Research Institute,Wuhan University of Technology,State Key Laboratory for Marine Corrosion and Protection,Luoyang Ship Material Research Institute,Wuhan University of Technology,State Key Laboratory for Marine Corrosion and Protection,Luoyang Ship Material Research Institute |
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| Abstract: | The development of green antifoulants is an important research direction of marine antifouling coatings, and the identification of antifouling active groups in the molecular structure of active compounds is the key to designing and developing new antifoulants. In this paper, three benzamide compounds HNOB, DOLPA and DHNOB with similar structure were synthesized, and their molecular structures were characterized by FTIR, 1H NMR and 13C NMR tests. The effects of the compounds on the adhesion of diatoms and mussels were tested. The molecular structures and antifouling activity were compared, and the active groups that affected antifouling performance were discussed. The adhesion experiments of diatom and mussel showed that HNOB had better antifouling performance, and its half inhibitory concentration was much lower than DOLPA and DHNOB. It was found that the synergistic effect of polar and non-polar structures was better than that of single polar group or non-polar long carbon chain group to endow benzamide with good antifouling performance. This study initially explores the conformational relationships of benzamide analogues, which can help the design and development of new antifoulants and structural optimization, and is important for rapid screening of promising antifoulants. |
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| Keywords: | benzamide compounds diatom attachment antifouling structure-activity relationship |
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