| 抗鳗弧菌单克隆抗体免疫保护作用的实验研究 |
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| 引用本文： | 夏永娟,黄威权,金晓航,姜国良,刘云.抗鳗弧菌单克隆抗体免疫保护作用的实验研究[J].海洋湖沼通报,2000(3):6-9. |
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| 作者姓名： | 夏永娟 黄威权 金晓航 姜国良 刘云 |
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| 作者单位： | 1. 第四军医大学组织学与胚胎学教研室,西安710032
2. 青岛海洋大学海洋生命学院,青岛266003 |
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| 基金项目： | 新材料领域项目，816-02-06， |
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| 摘 要： | 本文对鳗弧菌感染牙鲆幼鱼为动物模型，对我们制备的五株抗鳗弧菌单抗４Ａ６，３Ｂ２，４Ｅ１２，３Ｅ７，３Ａ４的免疫保护效果进行了研究，结果表明：４Ａ６，３Ｂ２和４Ｅ１２具有明显提高受５ＬＤ＾５０鳗弧菌感染的牙鲆存活率的作用，同时它们还可明显延长受大齐量鳗弧菌（１０ＬＤ＾５０）感染的牙鲆的平均存活时间，揭示：４Ａ６，３Ｂ２和４Ｅ１２具有中和或减弱鳗弧菌毒性的作用。
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| 关 键 词： | 鳗弧菌 单克隆抗体 免疫保护 鱼类 |
| 文章编号： | 1003-6482(2000)03-0006-04 |
PROTECTIVE PROPERTIES OF MONOCLONAL ANTIBODIES AGAINST VIBRIO ANGUILLARUM IN EXPERIMENTAL FLOUNDER |
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| XIA Yongjuan,HUANG Weiquan,JIN Xiaohang,JIANG Guoliang,LIU Yun.PROTECTIVE PROPERTIES OF MONOCLONAL ANTIBODIES AGAINST VIBRIO ANGUILLARUM IN EXPERIMENTAL FLOUNDER[J].Transaction of Oceanology and Limnology,2000(3):6-9. |
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| Authors: | XIA Yongjuan HUANG Weiquan JIN Xiaohang JIANG Guoliang LIU Yun |
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| Institution: | XIA Yongjuan
,HUANG Weiquan
,JIN Xiaohang
(Department of Histology and Embryology, Fourth Military Medical University, Xi'an 710032) JIANG Guoliang
,LIU Yun
(College of Marine Life Sciences, Ocean University of Qingdao, Qingdao, 266003) |
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| Abstract: | The protective properties of monoclonal antibodies (mAbs) against V. anguillarum were studied in experimental flounder paralichthys olivaceus. The results showed that: (l) the survival rate of flounder challenged with 5LD50 of V. anguillarum was significantly higher in 4A6, 3B2,and 4E12 groups than in the control group (P<0.01). (2) 4A6, 3B2 and 4E12 mAbs were effective in extending the mean time of survival of 'flounders challenged with 10LD50 of V anguillarum. These results indicated that 4A6, 3B2 and 4E12 mAbs had the ability to neutralize the pathological effects of V. anguillarum. |
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| Keywords: | vibrio anguillarum monoclonal antibody immunoprotection |
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