| 人体乳腺癌矿化的同步辐射研究 |
| |
| 引用本文： | 孟繁露,李源,李艳,王长秋,鲁安怀,梅放.人体乳腺癌矿化的同步辐射研究[J].岩石矿物学杂志,2015,34(6):957-962. |
| |
| 作者姓名： | 孟繁露 李源 李艳 王长秋 鲁安怀 梅放 |
| |
| 作者单位： | 造山带与地壳演化教育部重点实验室, 北京大学地球与空间科学学院, 北京 100871;造山带与地壳演化教育部重点实验室, 北京大学地球与空间科学学院, 北京 100871;造山带与地壳演化教育部重点实验室, 北京大学地球与空间科学学院, 北京 100871;造山带与地壳演化教育部重点实验室, 北京大学地球与空间科学学院, 北京 100871;造山带与地壳演化教育部重点实验室, 北京大学地球与空间科学学院, 北京 100871;北京大学医学部基础医学院病理学系, 北京 100083 |
| |
| 基金项目： | 国家自然科学基金资助项目(41272048,40872196) |
| |
| 摘 要： | 同步辐射具有常规光源不可比拟的优良性能,可用于微量生物矿化样品的物相、结构、形貌和成分研究。本文利用基于同步辐射光源的X射线粉末衍射(SR-XRD)、傅立叶变换红外光谱(SR-FTIR)、X射线荧光分析(SR-XRF)和X射线三维成像,对人体乳腺癌矿化进行了表征。研究表明,乳腺癌矿化的主要矿物物相为碳羟磷灰石,含有Sr、Zn等微量元素,其中砂粒体矿化具有独特的分层结构。研究结果为乳腺癌的病理研究和诊断提供了矿物学参考信息。
|
| 关 键 词： | 同步辐射 荧光 成像 肿瘤 钙化 磷灰石 |
| 收稿时间： | 2015/9/1 0:00:00 |
| 修稿时间： | 2015/9/30 0:00:00 |
Characterization of human breast cancer calcification using synchrotron radiation |
| |
| MENG Fan-lu,LI Yuan,LI Yan,WANG Chang-qiu,LU An-huai and MEI Fang.Characterization of human breast cancer calcification using synchrotron radiation[J].Acta Petrologica Et Mineralogica,2015,34(6):957-962. |
| |
| Authors: | MENG Fan-lu LI Yuan LI Yan WANG Chang-qiu LU An-huai and MEI Fang |
| |
| Institution: | Key Laboratory of Orogenic Belts and Crustal Evolution, MOE, School of Earth and Space Sciences, Peking University, Beijing 100871, China;Key Laboratory of Orogenic Belts and Crustal Evolution, MOE, School of Earth and Space Sciences, Peking University, Beijing 100871, China;Key Laboratory of Orogenic Belts and Crustal Evolution, MOE, School of Earth and Space Sciences, Peking University, Beijing 100871, China;Key Laboratory of Orogenic Belts and Crustal Evolution, MOE, School of Earth and Space Sciences, Peking University, Beijing 100871, China;Key Laboratory of Orogenic Belts and Crustal Evolution, MOE, School of Earth and Space Sciences, Peking University, Beijing 100871, China;Pathology Department, School of Basic Medical Science, Health Science Center of Peking University, Beijing 100083, China |
| |
| Abstract: | Synchrontron radiation performs much better than conventional light source in that it is capable of examining the mineral phase, crystal structure, morphology and chemical composition of biomineralizaiton samples in a tiny amount. Based on synchrontron radiation, the authors employed several test methods to study human breast cancer calcification, including X-ray diffraction, Fourier transform infrared spectroscopy, X-ray fluorescence and three-dimensional imaging. According to the results, breast cancer calcification is mainly composed of(carbonated) hydroxylapatite, with trace elements like Sr and Zn. The psammoma body holds special layered structure. These results provide mineralogical information for the pathological study and diagnosis of breast cancer. |
| |
| Keywords: | synchrontron radiation fluorescence mapping tumor calcification apatite |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《岩石矿物学杂志》浏览原始摘要信息 |
| 点击此处可从《岩石矿物学杂志》下载免费的PDF全文 |
|
