| 乳腺病变伴发生物矿化的类型及机制研究 |
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| 引用本文： | 梅放,柳剑英,张燕,王长秋,鲁安怀,赵文雯,熊翠娥,张波.乳腺病变伴发生物矿化的类型及机制研究[J].矿物学报,2011,31(4):704-712. |
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| 作者姓名： | 梅放 柳剑英 张燕 王长秋 鲁安怀 赵文雯 熊翠娥 张波 |
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| 作者单位： | 1. 北京大学医学部基础医学院病理学系／北京大学第三医院病理科,北京,100191
2. 北京大学造山带与地壳演化教育部重点实验室地球与空间科学学院,北京,100871 |
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| 基金项目： | 国家自然科学基金项目(批准号:40872196); 国家重点基础研究发展计划资助项目(973项目)(2007CB815602) |
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| 摘 要： | 乳腺病变伴发生物矿化的类型多样、机制复杂。本试验对手术切除或粗针穿刺获得的乳腺脂肪坏死标本5例、乳腺增生症8例、乳腺纤维腺瘤7例及乳腺浸润性癌或原位癌6例分别进行常规HE（苏木素-伊红）染色、普鲁士蓝、茜素红S、Masson三色特殊染色及Ⅲ型胶原、Ⅳ型胶原免疫组织化学染色,以观察各种病变伴发矿化的常规病理学改变及无机、有机成分的差异。染色结果显示各种矿化物的主要无机成分均为钙盐。脂肪坏死和纤维腺瘤伴发的矿化均与Ⅲ型胶原有关,乳腺增生症伴发的矿化与Ⅳ型胶原有关,而乳腺导管原位癌矿化与上述两种胶原的关系不大。根据形态可将乳腺病变伴发的生物矿化分为坏死相关性矿化及非坏死相关性矿化。前者又可分为肿瘤性坏死相关性矿化和非肿瘤性坏死相关性矿化。非坏死相关性矿化可分为上皮相关性矿化及间质相关性矿化。乳腺病变类型不同,其伴发矿化的机制也不尽相同。
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| 关 键 词： | 生物矿化 脂肪坏死 乳腺增生症 纤维腺瘤 乳腺癌 |
A Study on the Main Types and Formation Mechanisms of Biomineralization Associated with Breast Lesions |
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| MEI Fang,LIU Jian-ying,ZHANG Yan,WANG Chang-qiu,LU An-huai,ZHAO Wen-wen,XIONG Cui-e,ZHANG Bo.A Study on the Main Types and Formation Mechanisms of Biomineralization Associated with Breast Lesions[J].Acta Mineralogica Sinica,2011,31(4):704-712. |
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| Authors: | MEI Fang LIU Jian-ying ZHANG Yan WANG Chang-qiu LU An-huai ZHAO Wen-wen XIONG Cui-e ZHANG Bo |
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| Institution: | MEI Fang1,LIU Jian-ying1,ZHANG Yan1,WANG Chang-qiu2,LU An-huai2,ZHAO Wen-wen2,XIONG Cui-e2,ZHANG Bo1(1.Pathology Department,School of Basic Medical Sciences,Peking University/ Pathology Department,Peking University Third Hospital,Beijing 100191,2.The Key Laboratory of Orogenic Belts and Crustal Evolution,School of Earth and Space Sciences,Peking University,Beijing 100871) |
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| Abstract: | The main types and formation mechanisms of biomineralization associated with breast lesions are various and complicated.Surgical resection specimens or core needle biopsy specimens of 5 breast fat necroses,8 benign proliferative breast diseases,7 breast fibrous adenomas and 6 breast infiltrative carcinomas/carcinomas in situ were selected in our study.Each case was dyed with routine HE(Hematoxylin-Eosin) stain,special stain with Prussian blue,Alizarin red S and Trichrome Masson staining,and immunohistochemi... |
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| Keywords: | biomineralization fat necrosis benign proliferative breast disease fibrous adenoma breast cancer |
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