| 甲状腺乳头状癌组织坏死后矿化特征研究 |
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| 引用本文： | 王长秋,赵文雯,鲁安怀,李艳,熊翠娥,梅放,柳剑英.甲状腺乳头状癌组织坏死后矿化特征研究[J].矿物学报,2011,31(4):623-628. |
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| 作者姓名： | 王长秋 赵文雯 鲁安怀 李艳 熊翠娥 梅放 柳剑英 |
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| 作者单位： | 1. 北京大学造山带与地壳演化教育部重点实验室地球与空间科学学院,北京,100871
2. 北景大学医学部基础医学院病理学系,北京,100083 |
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| 基金项目： | 国家自然科学基金项目(40872196); 国家重点基础研究发展计划资助项目(973项目)(2007CB815602) |
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| 摘 要： | 组织坏死后矿（钙）化是甲状腺癌病灶中普遍存在的钙化形式之一,与病变关系密切。利用光学显微镜、环境扫描电镜、高分辨透射电镜及显微红外光谱研究了6例甲状腺乳头状癌中的组织坏死后矿化特征。结果表明,组织坏死后矿化往往发生在胶原纤维丰富的位置,与胶原关系密切。矿化表现出2种形态,矿（钙）化灶内为较为致密的隐晶集合体,其表面及其附近的胶原上沉淀有许多微米级矿化小球,离矿化灶较远的胶原纤维上也散布有矿化小球。一些矿化小球边缘还发育絮状矿化物质,使之形成绒球状外貌。矿化物质结晶程度均较差,由纳米多晶组成。钙化灶中央较致密部分的n（Ca）/n（P）比较高,接近羟基磷灰石的理论比值,而其边缘以及矿化小球的n（Ca）/n（P）比均较低,可能含有磷酸八钙等低n（Ca）/n（P）磷酸钙系列矿物。矿化初期形成纳米多晶组成的微米级矿化小球,矿化小球逐渐聚集形成大面积的矿化灶。
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| 关 键 词： | 矿化 组织坏死 甲状腺乳头状癌 |
Characteristics on Mineralization Resulted from Tissue Necrosis in Papillary Thyroid Carcinoma |
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| WANG Chang-qiu,ZHAO Wen-wen,LU An-huai,LI Yan,XIONG Cui-e,MEI Fang,LIU Jian-ying.Characteristics on Mineralization Resulted from Tissue Necrosis in Papillary Thyroid Carcinoma[J].Acta Mineralogica Sinica,2011,31(4):623-628. |
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| Authors: | WANG Chang-qiu ZHAO Wen-wen LU An-huai LI Yan XIONG Cui-e MEI Fang LIU Jian-ying |
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| Institution: | WANG Chang-qiu1,ZHAO Wen-wen1,LU An-huai1,LI Yan1,XIONG Cui-e1,MEI Fang2,LIU Jian-ying2(1.Key Laboratory of Orogenic Belts and Crustal Evolution,MOE,School of Earth and Space Sciences,Peking University,Beijing 100871,China,2.Pathology Department in School of Basic Medical Science,Peking University Health Science Center,Beijing 100083,China) |
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| Abstract: | As a common form of calcification in papillary thyroid carcinoma,the mineralization resulted from tissue necrosis is closely related to the development of disease.The characteristics of mineralization from tissue necrosis of 6 papillary thyroid carcinoma were investigated using optical microscope,environmental scan electron microscope(ESEM),high-resolution transmission electron microscope(TEM) and micro-Fourier transform infrared spectroscope(FTIR).The results indicate that the mineralization often occurs i... |
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| Keywords: | mineralization tissue necrosis papillary thyroid carcinoma |
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