This paper presents the analyses of twelve prestressed concrete (PSC) instrumented test piles that were driven in different bridge construction projects of Louisiana in order to develop analytical models to estimate the increase in pile capacity with time or pile setup. The twelve test piles were driven mainly in cohesive soils. Detailed soil characterizations including laboratory and in situ tests were conducted to determine the different soil properties. The test piles were instrumented with vibrating wire strain gauges, piezometers, pressure cells that were monitored during the whole testing period. Several static load tests (SLTs) and dynamic load tests were conducted on each test pile at different times after end of driving (EOD) to quantify the magnitude and rate of setup. Measurements of load tests confirmed that pile capacity increases almost linearly with the logarithm of time elapsed after EOD. Case pile wave analysis program was performed on the restrikes data and was used along with the load distribution plots from the SLTs to evaluate the increase in skin friction capacity of individual soil layers along the length of the piles. The logarithmic linear setup parameter “A” for unit skin friction was calculated of the 70 individual clayey soil layers and was correlated with different soil properties such as undrained shear strength (S_u), plasticity index, vertical coefficient of consolidation (c_v), over consolidation ratio and sensitivity (S_t). Nonlinear multivariable regression analyses were performed, and three different empirical models are proposed to predict the pile setup parameter “A” as a function of soil properties. For verification, the subsurface soil conditions and setup information for additional 18 PSC piles collected from local database were used to compare the measured versus predicted “A” parameters from the proposed models, which showed good agreement.