| 胃肠酸度下中药及补铁制剂中铁活性的影响研究 |
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| 引用本文： | 刘淑娟,王达成,杨沁羽.胃肠酸度下中药及补铁制剂中铁活性的影响研究[J].华东地质学院学报,2006,29(2):159-163. |
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| 作者姓名： | 刘淑娟 王达成 杨沁羽 |
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| 作者单位： | 东华理工学院化学生物与材料科学学院 江西抚州344000(刘淑娟，杨沁羽)，中国人民武装警察部队黄金第九支队实验室 海南海口570216(王达成) |
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| 基金项目： | 东华理工学院校科研和教改项目 |
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| 摘 要： | 在人体胃肠液的酸度条件下,采用正辛醇-水分配体系模拟药物在人体肠胃中的分配情况,研究了中药和补铁制剂中铁的形态及其在人体内的吸收情况,并探讨了中药不同比例的配伍、胃肠酸度及还原性物质的存在对水溶态铁和醇溶态铁的影响。结果表明,药物溶液中的铁形态与药物本身特性和配伍情况有关,酸度及配伍对药物中铁的溶出率和溶液中铁的形态有较大影响,人体对铁的吸收与胃肠酸度和还原性物质的存在有关。
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| 关 键 词： | 铁形态 胃肠液酸度 正辛醇 |
| 文章编号： | 1000-2251(2006)02-159-05 |
| 收稿时间： | 2006-01-10 |
| 修稿时间： | 2006年1月10日 |
Study of Iron Speciation in Chinese Medicines and Iron oral liquids at Gastric and Intestinal Acidity |
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| LIU Shu-juan,WANG Da-cheng,YANG Qin-yu.Study of Iron Speciation in Chinese Medicines and Iron oral liquids at Gastric and Intestinal Acidity[J].Journal of East China Geological Institute,2006,29(2):159-163. |
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| Authors: | LIU Shu-juan WANG Da-cheng YANG Qin-yu |
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| Institution: | 1. Faculty of Chemitry Biology and Materials Science, East China Institute of Technology, Fuzhou, JX 344000, China; 2. No. 9 Gold Geological Party of the Armed Police Force, Haikou, HN 570216, China |
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| Abstract: | At the pH of gastric and intestinal,the normal octanol-water partition system is used to simulate the iron distribution in the human stomach and intestine.Iron speciation of the decoctions of traditional Chinese medicines and iron oral liquids is analyzed to study the iron absorption of human body.The effects of different compatibilities of medicines,pH and reducing reagent on iron speciation are investigated in details.Results show that the distribution of iron species in medicine solution is affected by the nature of medicines and their compatibility.Gastric and intestinal pH effects the iron absorption a lot.The reducing reagent can promote iron absorption. |
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| Keywords: | Iron speciation gastric and intestinal pH n-C_8H_(17)OH |
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