Preparation and biological efficacy of haddock bone calcium tablets |
| |
| Authors: | Jiancong Huo Shanggui Deng Chao Xie Guozhong Tong |
| |
| Institution: | (1) Department of Nephrology, Great Ormond Street Hospital for Children NHS Trust, London, UK;(2) Renal Office, Great Ormond Street Hospital for Children, Great Ormond Street, London, WC1N 3JH, UK |
| |
| Abstract: | To investigate the possible use of waste products obtained after processing haddock, the present study prepared haddock bone
calcium powder by NaOH and ethanol soaking (alkalinealcohol method) and prepared haddock bone calcium tablets using the powder
in combination with appropriate excipients. The biological efficacy of the haddock bone calcium tablets was investigated using
Wistar rats as an experiment model. Results show that the optimal parameters for the alkalinealcohol method are: NaOH concentration
1 mol/L, immersion time 30 h; ethanol concentration 60%, immersion time 15 h. A mixture of 2% polyvinylpyrrolidone in ethanol
was used as an excipient at a ratio of 1:2 to full-cream milk powder, without the use of a disintegrating agent. This process
provided satisfactory tablets in terms of rigidity and taste. Animal studies showed that the haddock bone calcium tablets
at a dose of 2 g·kg−1·d−1 or 5g·kg−1·d−1 significantly increased blood calcium and phosphorus levels and bone calcium content in rats. Therefore, these tablets could
be used for calcium supplementation and prevent osteoporosis. Although the reasons of high absorption in the rats fed with
haddock bone calcium tablets are unclear, it is suggested that there are some factors, such as treatment with method of alkaline-alcohol
or the added milk, may play positive roles in increasing absorption ratio. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
