| Effects of polypeptide from Chlamys farreri on amino acid con-tent in guinea pig skin irradiated by chronic ultraviolet A and B |
| |
| 作者姓名： | 于国英 曹鹏利 郭昆 王跃军 孙谧 王春波 |
| |
| 作者单位： | Affiliated Hospital of Medical College，Qingdao University，Qingdao 266003，China，Affiliated Hospital of Medical College，Qingdao University，Qingdao 266003，China，Affiliated Hospital of Medical College，Qingdao University，Qingdao 266003，China，Affiliated Hospital of Medical College，Qingdao University，Qingdao 266003，China，Affiliated Hospital of Medical College，Qingdao University，Qingdao 266003，China，Affiliated Hospital of Medical College，Qingdao University，Qingdao 266003，China |
| |
| 基金项目： | Project No. 39970638 supported by the NSFC，and also supported by the Science and Technology Bureau of Qingdao (No: 2001- 28- 50). |
| |
| 摘 要： | 1 INTRODUCTION Long-term exposure of the skin to ultraviolet (UV) radiation results in degenerative processes involved in photoaging and photocarcinogenesis (Differy, 1987). As UVC is absorbed entirely by the stratospheric ozone layer and does not reach the earth抯 surface, sunlight is composed of UVA (320 nm 400 nm) and UVB (290 nm 320 nm). Human skin is exposed constantly to both UVA and UVB radiation, it is, therefore, important to protect the skin against UVA and UVB-induce…
|
Effects of polypeptide from Chlamys farreri on amino acid content in guinea pig skin irradiated by chronic ultraviolet A and B |
| |
| YU Guoying CAO Pengli ,GUO Kun,WANG Yuejun SUN Mi,WANG Chunbo.Effects of polypeptide from Chlamys farreri on amino acid con-tent in guinea pig skin irradiated by chronic ultraviolet A and B[J].Chinese Journal of Oceanology and Limnology,2004,22(4). |
| |
| Authors: | YU Guoying CAO Pengli GUO Kun WANG Yuejun SUN Mi WANG Chunbo |
| |
| Abstract: | We examined the effects of polypeptide from Chlamys farreri (PCF) on the amount of hy-droxyproline in guinea pig skin irradiated by chronic ultraviolet A (UVA) and ultraviolet B (UVB) radiation. PCF was applied locally before repeated exposure of guinea pig to UVA and UVB. The contents of hy-droxyproline and other amino acids in guinea pig skin were determined by automatic amino acid analyzer. Our results showed that: (1) long-time UVA and UVB radiation can reduce dramatically the amounts of hy-droxyproline, aspartic acid, threonine, glycine, phenylalanine and lysine in guinea pig skin in comparison with the control group (P < 0.05); (2) Compared with model group, pre-treatment with 5 % and 20 % PCF prior to UVA and UVB radiation can inhibit the decline of amino acids content in guinea pig skin in a dose-dependent manner (P < 0.05). As the decrease of hydroxyproline, glycine and lysine contents in the skin directly reflexes type I collagen degeneration, our results indicated that the chronic application of PCF can protect skin type I collagen against UV radiation, and thus protect skin from photoaging. |
| |
| Keywords: | polypeptide from Chlamys farreri ultraviolet radiation hydroxyproline photoaging guinea pig |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
