Optimized water vapor permeability of sodium alginate films using response surface methodology |
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| Authors: | Qing Zhang Jiachao Xu Xin Gao Xiaoting Fu |
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| Institution: | 1. College of Food Science and Engineering, Ocean University of China, Qingdao, 266003, China
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| Abstract: | The water vapor permeability (WVP) of films is important when developing pharmaceutical applications. Films are frequently used as coatings, and as such directly influence the quality of the medicine. The optimization of processing conditions for sodium alginate films was investigated using response surface methodology. Single-factor tests and Box-Behnken experimental design were employed. WVP was selected as the response variable, and the operating parameters for the single-factor tests were sodium alginate concentration, carboxymethyl cellulose (CMC) concentration and CaCl2 solution immersion time. The coefficient of determination (R 2) was 0.97, indicating statistical significance. A minimal WVP of 0.389 8 g·mm/(m2·h·kPa) was achieved under the optimum conditions. These were found to be a sodium alginate concentration, CMC concentration and CaCl2 solution immersion time at 8.04%, 0.13%, and 12 min, respectively. This provides a reference for potential applications in manufacturing film-coated hard capsule shells. |
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| Keywords: | sodium alginate film water vapor permeability （WVP） response surface analysis |
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