Polypeptide from Chlamys farreri inhibits UVB-induced apoptosis of HaCaT cells via iNOS/NO and HSP90 |
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| Authors: | Zhang Zhengyang Liu Xiaojin Liu Tuo Yan Lin Wang Yuejun Wang Chunbo |
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| Institution: | [1]Department of Pharmacology, Medical College of Qingdao University, Qingdao 266071, China [2]Department of Public Health, Medical College of Qingdao University, Qingdao 266071, China [3]yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China |
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| Abstract: | Polypeptide from Chlamys farreri(PCF) is a novel marine bioactive product that was isolated from the gonochoric Chinese scallop Chlamys farreri,and was found to be an effective antioxidant in our recent studies.In this study,we investigated the effect of PCF on ultraviolet B(UVB)-induced apoptosis of HaCaT cells and the intracellular signaling pathways involved.Pretreatment with the inducible nitric oxide synthase(iNOS) inhibitor S-methylisothiourea sulfate inhibited UVB-induced apoptosis,indicating that iN... |
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| Keywords: | apoptosis HaCaT cells HSP iNOS/NO Polypeptide from Chlamys farreri (PCF) ultraviolet B (UVB) |
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