The preparation and antioxidant activity of glucosamine sulfate |
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| Authors: | Ronge Xing Song Liu Lin Wang Shengbao Cai Huahua Yu Jinhua Feng Pengcheng Li |
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| Institution: | (1) Institute of Oceanology, Chinese Academy of Sciences, Qingdao, 266071, China;(2) Graduate School of Chinese Academy of Sciences, Beijing, 100039, China |
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| Abstract: | Glucosamine sulfate was prepared from glucosamine hydrochloride that was produced by acidic hydrolysis of chitin by ion-exchange
method. Optical rotation and elemental analysis characterized the degree of its purity. In addition, the antioxidant potency
of chitosan derivative-glucosamine sulfate was investigated in various established in vitro systems, such as superoxide (O2−)/hydroxyl (·OH) radicals scavenging, reducing power, iron ion chelating. The following results are obtained: first, glucosamine
sulfate had pronounced scavenging effect on superoxide radical. For example the O2− scavenging activity of glucosamine sulfate was 92.11% at 0.8 mg/mL. Second, the ·OH scavenging activity of glucosamine sulfate
was also strong, and was about 50% at 3.2 mg/mL. Third, the reducing power of glucosamine sulfate was more pronounced. The
reducing power of glucosamine sulfate was 0.643 at 0.75 mg/mL. However, its potency for ferrous ion chelating was weak. Furthermore,
except for ferrous ion chelating potency, the scavenging rate of radical and reducing power of glucosamine sulfate were concentration-dependent
and increased with their increasing concentrations, but its ferrous ion chelating potency decreased with the increasing concentration.
The multiple antioxidant activities of glucosamine sulfate were evidents of reducing power and superoxide/hydroxyl radicals
scavenging ability. These in vitro results suggest the possibility that glucosamine sulfate could be used effectively as an ingredient in health or functional
food, to alleviate oxidative stress.
Supported by the Talent Program of Chinese Academy of Sciences (Dongbei Zhi Chun) and Award Foundation of Scientific Research
for Excellent Young and Middle-Age Scientist of Shandong Province (No. 2007BS07002) |
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| Keywords: | Keyword" target="_blank">Keyword glucosamine sulfate ion-exchange method radical scavenging effect reducing power chelating effect |
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