Protective effects of C-phycocyanin on alcohol-induced acute liver injury in mice |
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| Authors: | Dong Xia Bing Liu Xiying Luan Junyan Sun Nana Liu Song Qin Zhenning Du |
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| Institution: | 1.School of Pharmacy,Yantai University,Yantai,China;2.Key Laboratory of Coastal Biology and Bioresource Utilization, Yantai institute of Coastal Zone Research,Chinese Academy of Sciences,Yantai,China;3.School of Basic Medical,Binzhou Medical University,Yantai,China |
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| Abstract: | Excessive alcohol consumption leads to liver disease. Extensive evidence suggests that C-phycocyanin (C-PC), a chromophore phycocyanobilin derived from Spirulina platensis, exerts protective effects against chemical-induced organ damage. In this study, we investigated whether C-PC could protect against ethanol-induced acute liver injury. Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride (TG), total cholesterol (CHOL), low-density lipoprotein (LDL), liver homogenate malondialdehyde (MDA), superoxide dismutase (SOD) content were measured, and pathological examination of liver sections were examined. C-PC showed obvious inhibitory effects on serum ALT, AST, TG, CHOL, LDL and MDA, and SOD content significantly increased in the liver. The structure of hepatic lobules was clear, liver sinus returned to normal, and liver cell cords were arranged in neat rows. Cloudiness, swelling, inflammatory cell infiltration and spotty necrosis of liver cells were significantly reduced. Therefore, C-PC can significantly protect against ethanol-induced acute liver injury. |
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